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Mammary gland immunogram of goats naturally infected with Caprine Encephalitis Arthritis

Grant number: 09/13410-7
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): March 01, 2010
Effective date (End): February 29, 2012
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
Principal Investigator:Alice Maria Melville Paiva Della Libera
Grantee:Bruna Parapinski dos Santos
Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil


The caprine arthritis encephalitis (CAE) is a disease caused by a lentivirus. This disease has a tropism to monocytes/macrophages cells. It is important, because can infect the herds and generally induces the clinical manifestations to a cronicity. Caprine arthritis encephalitis virus can cause mammary gland effect like endurative mastitis. The aim of this study is to evaluate the sistemic and/or mammary alterations. First, 20 goats divided in two groups will be selected from 100 goats in lactation according to the results of immunodiffusion test to CAE. The results will be share in: group 1 animals non-infected and group 2 animals CAE-infected. For this evaluation will be performed: strip cup test, Califórnia Mastitis Test (CMT), bacteriological exam, count cell somatic of milk and the functional evaluation of the blood and milk leukocytes based on phagocytosis rates, intracellular hydrogen peroxide production, cellular death, immunophenotipagem of leukocytes, cytokines IL-4 and IFN-³ quantification and immunoglobulins IgG, IgM, IgA quantification.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SANTOS, BRUNA PARAPINSKI; SOUZA, FERNANDO NOGUEIRA; BLAGITZ, MAIARA GARCIA; BATISTA, CAMILA FREITAS; BERTAGNON, HELOISA GODOI; DINIZ, SORAIA ARAUJO; SILVA, MARCOS XAVIER; AMARAL HADDAD, JOAO PAULO; PAIVA DELLA LIBERA, ALICE MARIA MELVILLE. Blood and milk polymorphonuclear leukocyte and monocyte/macrophage functions in naturally caprine arthritis encephalitis virus infection in dairy goats. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, v. 188, p. 21-26, . (09/13410-7, 10/07716-3)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SANTOS, Bruna Parapinski dos. Influence of caprine arthritis encephalitis virus on blood and milk immunogram of naturally infected goats. 2012. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina Veterinária e Zootecnia (FMVZ/SBD) São Paulo.

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