Role of Statins in in Myocardial Injury and Inflammatory Markers in Patients Undergoing Elective Implantation of "Stent

• Grant number: 10/08440-1
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: November 01, 2010
• End date: October 31, 2011
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Carlos Vicente Serrano Junior
• Grantee: Karina Tiemi Setani
• Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

The percutaneous coronary intervention causes damage to the arterial wall leading to increased inflammatory markers such as C-reactive protein (CRP), tumor necrosis factor (TNF alpha) and interleukin (IL-1, IL-6 and IL-8). As tissue injury peri-procedure maintains a close relationship with the level of inflammatory activity, we must consider the level of activation of inflammatory cells before the procedure, because the inflammatory response will be more severe the higher the level of pre-cells activation immune system.Statins are being administered on a large scale among patients suffering from coronary artery disease by its power to reduce cholesterol levels, important risk factor related to coronary syndromes for its characteristic of inflammatory modulator, reducing the production of systemic inflammatory markers and for its anticoagulant action, causing vasodilation. Existing studies have assessed the relationship between prior use of statins and elevated markers of myocardial necrosis after elective implantation of stents. Missing, however, a better assessment of inflammation markers in such a situation, which will add in this study.