Mapping hemodynamic response delay in primary auditory cortex functional magnetic resonance imaging under CO2 different partial pressures

• Grant number: 06/05272-5
• Support Opportunities: Scholarships in Brazil - Master
• Start date: September 01, 2007
• End date: February 28, 2009
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Draulio Barros de Araujo
• Grantee: Kelley Cristine Mazzetto Betti
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

The brain is vulnerable to sanguineous aport disturb. Nerveless the cerebral vascular system present special characteristics to avoid large circulatory variations. Patients that present cerebrovascular disease, like carotid stenosis, have a cerebral vasoregulation deficit, which can lead to isquemic events. An efficient mechanism to assess the vasorregulatory process is the BOLD effect utilization, often used to get functional images by magnetic resonance. The aim of this study is look for specific characteristics of the hemodynamic function response and assess these properties on both cerebral hemifields under different levels of CO2 inhalation. This modulation will be assessed during an auditory stimulus in volunteers, to after be applied in patients with severe carotid stenosis or unilateral carotid occlusion.