The aim of this study is to evaluate the bispectral index and the hemodynamic and respiratory effects of continuous rate infusion of propofol in calves. For such, eight calves with eight to 12 months of age, Holstein, weighing 100-150 kg will be used. The animals will be induced to anesthesia with propofol at a dose of 3 mg/kg, intravenously and intubated with tracheal tubes of size compatible to animals' size and positioned in right lateral recumbency. Immediately after the maintenance will be performed by continuous rate infusion of propofol, administered at two different rates, 0.6 mg/kg/minute and 0.8 mg/kg/min. In half of the animals (n=4) the experimental protocol will beginning with a rate of 0.6 mg/kg/minute during the first 40 minutes and after, the rate will be increased to 0.8 mg/kg/minute for 40 minutes. In the other half of the animals (n=4) the experimental protocol will beginning with the highest rate (0.8 mg/kg/minute) for 40 minutes and after it will be reduced (0.6 mg/kg/minutes) for 40 minutes, performing 80 minutes of propofol infusion in two different rates. Measurements of hemodynamic parameters (HR, SAP, DAP, MAP, CO, CVP, mPAP, PAPOm, CI, SI, SVR and PVR) and respiratory (ETCO2, SpO2 and f) and bispectral index (BIS and EMG) will be evaluated before anesthesia (MB) and 20, 40, 60 and 80 minutes after continuous infusion rate of propofol (M20, M40, M60 and M80, respectively). Data from the BIS and EMG will be submitted to one-way ANOVA, and the others variables will be submitted to ANOVA followed by Bonferroni test (p<0.05).
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