|Support type:||Scholarships in Brazil - Master|
|Effective date (Start):||March 01, 2011|
|Effective date (End):||February 29, 2012|
|Field of knowledge:||Agronomical Sciences - Veterinary Medicine - Animal Pathology|
|Principal Investigator:||Noeme Sousa Rocha|
|Home Institution:||Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil|
Melanomas in dogs and humans are responsible for much of skin cancer. Usually the diagnosis is associated with a poor prognosis, since the biological behavior is unpredictable. In this context, the characterization of stromal fibroblasts is of great importance since they can influence all stages of carcinogenesis, and may become potential therapeutic targets. Stromal fibroblasts may originate from several sources, including the endothelium. To date there are no studies concerning the contribution of endothelial population to the stromal fibroblast population in sporadic melanomas. The objective of this study is to characterize the immunophenotype of fibroblasts associated with sporadic cutaneous melanoma canines using endothelial CD31), smooth muscle (±-SMA) and fibroblast (S100A4) cell markers in order to evaluate the contribution of the endothelial-to-mesenchymal transition in the formation of this population and establish a correlation with vascular microdensity (VM.