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Cancer-associated fibroblasts and correlation with pathological parameters in canine cutaneous melanomas

Grant number: 10/14317-8
Support type:Scholarships in Brazil - Master
Effective date (Start): March 01, 2011
Effective date (End): February 29, 2012
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Pathology
Principal Investigator:Noeme Sousa Rocha
Grantee:Fabrizio Grandi
Home Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Melanomas in dogs and humans are responsible for much of skin cancer. Usually the diagnosis is associated with a poor prognosis, since the biological behavior is unpredictable. In this context, the characterization of stromal fibroblasts is of great importance since they can influence all stages of carcinogenesis, and may become potential therapeutic targets. Stromal fibroblasts may originate from several sources, including the endothelium. To date there are no studies concerning the contribution of endothelial population to the stromal fibroblast population in sporadic melanomas. The objective of this study is to characterize the immunophenotype of fibroblasts associated with sporadic cutaneous melanoma canines using endothelial CD31), smooth muscle (±-SMA) and fibroblast (S100A4) cell markers in order to evaluate the contribution of the endothelial-to-mesenchymal transition in the formation of this population and establish a correlation with vascular microdensity (VM.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GRANDI, FABRIZIO; ROCHA, RAFAEL M.; MIOT, HELIO A.; COGLIATI, BRUNO; ROCHA, NOEME S. Immunoexpression of S100A4 in canine skin melanomas and correlation with histopathological parameters. VETERINARY QUARTERLY, v. 34, n. 2, p. 98-104, 2014. Web of Science Citations: 3.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
GRANDI, Fabrizio. Fibroblastos associados ao câncer e correlação com parãmetros patológicos em melanomas cutâneos caninos. 2012. 87 f. Master's Dissertation - Universidade Estadual Paulista "Júlio de Mesquita Filho" Faculdade de Medicina..

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