Features and prognosis of prostate cancer in different age groups: a matched paired analysis

• Grant number: 10/17839-5
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: February 01, 2011
• End date: December 31, 2011
• Field of knowledge: Health Sciences - Medicine - Surgery
• Principal Investigator: Miguel Srougi
• Grantee: José Arnaldo Shiomi da Cruz
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Prostate cancer is the most common malignant neoplasm among men worldwide. Several prognostic factors have been accepted in the literature like Gleason score, PSA levels, and percentage of positive fragments at the prostate biopsy. Nevertheless, age has not been formally studied as a prognostic factor in an independently from the already known prognostic factors. The purpose of this study is to compare in different age groups the features and evolution of prostate cancer in patients whose main known prognostic factors are equivalent through a controlled matched-paired analysis in order to analyse the variable age separately from the other prognostic factors already accepted in the literature and determine the real impact of age in the prognosis of prostate cancer. (AU)