Detection of the antibody anti-PGL-1 in the saliva of leprosy patients as an exposition parameter to Mycobacterium leprae and diasease activity.

• Grant number: 10/20503-9
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: February 01, 2011
• End date: January 31, 2013
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Ana Carolina Fragoso Motta
• Grantee: Leandro Issao Takeuchi
• Host Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Leprosy is a chronic infectious disease caused by Mycobacterium leprae, an acid-fast bacillus that presents a peculiar tropism for peripheral nerves and the skin. The prevalence of leprosy in the world has declined since the introduction of the multidrug therapy (MDT) recommended by the World Health Organization (WHO, 1982). However, leprosy is still a public health problem. The upper airways has a great importance as a route of Mycobacterium leprae infection and because of the possibility of identifying relevant tools by systematic patient evaluation,the detection of leprosy patients by means of salivary markers becomes important. The aim of this study was to analyze anti-phenolic glycolipid 1 (anti-PGL-1) salivary and serum titers as parameters for correlation with infection, antigen exposure and treatment response. Approach: Leprosy patientsbefore, during and after specific treatment for leprosy will be selected. Salivary and serum anti-PGL-1 levels will be determined by Enzyme-Linked Immunosorbent Assay (ELISA) in leprosy patients, operational contacts and healthy control.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

RODRIGUES, G. A.; QUALIO, N. P.; DE MACEDO, L. D.; INNOCENTINI, L. M. A. R.; RIBEIRO-SILVA, A.; FOSS, N. T.; FRADE, M. A. C.; MOTTA, A. C. F.. The oral cavity in leprosy: what clinicians need to know. ORAL DISEASES, v. 23, n. 6, p. 749-756, SEP 2017. (11/18235-9, 10/20503-9, 14/16732-3)