Role of TLR-4 in experimental arterial hypertension: evaluation of cardiovascular parameters

• Grant number: 10/13829-5
• Support Opportunities: Scholarships in Brazil - Master
• Start date: March 01, 2011
• End date: August 31, 2012
• Field of knowledge: Health Sciences - Pharmacy
• Principal Investigator: Maria Helena Catelli de Carvalho
• Grantee: Cinthya Echem de Souza Pereira
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Arterial hypertension is considered as a main risk factor for the development of cardiovascular disease (CVDs). As a consequence, hypertension, leads to cardiac hypertrophy and a low degree chronic inflammation, with an increase in circulating pro-inflammatory cytokines. Toll-Like Receptors (TLR) family was identified as one of the major factors involved in innate immune response and its activation also induces pro-inflammatory cytokines production. Recent studies relate TLRs and CVDs, indicating the involvement of TLR4, however the participation of TLR4 in cardiac remodeling is still unknown. Thus, the objective of the present study was to evaluate the role of TLR4 in cardiac remodeling observed of spontaneously hypertensive rats (SHR). (AU)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

PEREIRA, Cinthya Echem de Souza. Role of TLR4 in cardiac remodeling process of spontaneously hypertensive rats - SHR.. 2012. Master's Dissertation - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.