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Role of sensory fibers of the kidney in cardiac and central changes in the 5/6 nephrectomy model in wistar rats

Grant number: 19/21759-1
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): February 01, 2020
Effective date (End): January 31, 2021
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal researcher:Erika Emy Nishi
Grantee:Yan de Paula Donetti
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

The sympathetic nervous system has been highlighted as an important therapeutic target for arterial hypertension (AH) by using renal denervation in patients and experimental models. Clinical studies in patients with chronic kidney disease (CKD) have shown that renal denervation, which destroys both sympathetic and sensory fibers that innervate the kidney, promotes not only renoprotective effects, but also improves cardiac and vascular function. The aim of this project is to evaluate whether the denervation of renal sensory fibers selectively can improve cardiac and central changes involved in the maintenance of AH in rats with CKD. CKD will be induced by the experimental 5/6 nephrectomy model in Wistar rats. After 5 weeks of CKD induction, the animals will undergo selective denervation of the afferent renal fibers and, after 3 weeks, the following parameters will be evaluated: blood pressure, heart rate, baroreceptor reflex sensitivity, reactive oxygen species in sympathetic premotor nuclei (PVN and RVL) and cardiac remodeling markers and hypertrophy. Therefore, the present project intends to advance the understanding of the mechanisms that contribute to AH and the development of new therapeutic strategies in CKD. (AU)