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Effects of renal denervation in a model of chronic kidney disease

Grant number: 18/11909-3
Support type:Scholarships in Brazil - Master
Effective date (Start): November 01, 2018
Effective date (End): June 30, 2020
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal researcher:Cassia Marta de Toledo Bergamaschi
Grantee:Amanda Costa Veiga
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

Chronic kidney disease (CKD) is characterized by progressive damage and irreversible loss of renal function. The main causes of CKD are cardiovascular diseases, mainly arterial hypertension (AH). Despite advances in pharmacological treatments with antihypertensives and surgical techniques, the increasing number of patients with CKD indicates the need for new therapeutic strategies. Clinical and experimental studies have demonstrated that the renal denervation procedure promotes not only renoprotective effects, but also improvement in cardiac and vascular function and glucose metabolism and insulin sensitivity, indicating effects on other target organs through neurohumoral mechanisms. In CKD, several mechanisms lead to cardiac and renal changes, such as fibrosis, proteinuria and activation of the renin-angiotensin-aldosterone system (RAAS) and increased sympathetic drive. The present project intends to study the underlying mechanisms of renal denervation on cardiovascular and renal improvements in CKD. The experimental model of 5/6 nephrectomy (Nx) will be performed in Wistar rats to induce CKD. Animals will undergo renal denervation and / or blockade of RAAS, and the following parameters will be evaluated: blood pressure, heart rate, renal and splanchnic sympathetic nerve activity, renal function markers. Thus, the present project aims to understand the functional and molecular mechanisms involved in CKD progression, associated with AH, contributing to the development and improvement of new treatments.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VEIGA, AMANDA C.; MILANEZ, MAYCON I. O.; CAMPOS, RUY R.; BERGAMASCHI, CASSIA T.; NISHI, ERIKA E. The involvement of renal afferents in the maintenance of cardiorenal diseases. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, v. 320, n. 1, p. R88-R93, JAN 2021. Web of Science Citations: 0.
MILANEZ, MAYCON I. O.; VEIGA, AMANDA C.; MARTINS, BEATRIZ S.; PONTES, ROBERTO B.; BERGAMASCHI, CASSIA T.; CAMPOS, RUY R.; NISHI, ERIKA E. Renal Sensory Activity Regulates the gamma-Aminobutyric Acidergic Inputs to the Paraventricular Nucleus of the Hypothalamus in Goldblatt Hypertension. FRONTIERS IN PHYSIOLOGY, v. 11, DEC 15 2020. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.