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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The involvement of renal afferents in the maintenance of cardiorenal diseases

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Author(s):
Veiga, Amanda C. [1] ; Milanez, Maycon I. O. [1] ; Campos, Ruy R. [1] ; Bergamaschi, Cassia T. [1] ; Nishi, Erika E. [1]
Total Authors: 5
Affiliation:
[1] Univ Fed Sao Paulo, Dept Physiol, Cardiovasc Div, Escola Paulista Med, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Review article
Source: AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY; v. 320, n. 1, p. R88-R93, JAN 2021.
Web of Science Citations: 0
Abstract

Elevated sympathetic vasomotor activity is a common feature of cardiorenal diseases. Therefore, the sympathetic nervous system is an important therapeutic target, particularly the fibers innervating the kidneys. In fact, renal denervation has been applied clinically and shown promising results in patients with hypertension and chronic kidney disease. However, the underlying mechanisms involved in the cardiorenal protection induced by renal denervation have not yet been fully clarified. This mini-review highlights historical and recent aspects related to the role of renal sensory fibers in the control of cardiorenal function under normal conditions and in experimental models of cardiovascular disease. Results have demonstrated that alterations in renal sensory function participate in the maintenance of elevated sympathetic vasomotor activity and cardiorenal changes; as such, renal sensory fibers may be a potential therapeutic target for the treatment of cardiorenal diseases. Although it has not yet been applied in clinical practice, selective afferent renal denervation may be promising, since such an approach maintains efferent activity and can provide more refined control of renal function compared with total renal denervation. However, more studies are needed to understand the mechanisms by which renal afferents partially contribute to such changes, in addition to the need to evaluate the safety and advantages of the approach for application in the clinical practice. (AU)

FAPESP's process: 18/01898-4 - Evaluation of brain-spinal projections in the temporal establishment of renal sympathetic hyperactivation in Renovascular Hypertension
Grantee:Maycon Igor de Oliveira Milanez
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 18/02671-3 - Functional and molecular actions of renal nerve in experimental chronic renal failure
Grantee:Cassia Marta de Toledo Bergamaschi
Support Opportunities: Regular Research Grants
FAPESP's process: 18/11909-3 - Effects of renal denervation in a model of chronic kidney disease
Grantee:Amanda Costa Veiga
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 17/03905-5 - Evaluation of renal afferent innervation influence in experimental chronic kidney disease
Grantee:Amanda Costa Veiga
Support Opportunities: Scholarships in Brazil - Scientific Initiation