Evaluation of brain-spinal projections in the temporal establishment of renal sympathetic hyperactivation in Renovascular Hypertension

• Grant number: 18/01898-4
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: August 01, 2018
• End date: January 31, 2022
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Ruy Ribeiro de Campos Junior
• Grantee: Maycon Igor de Oliveira Milanez
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

The increase of the Sympathetic Nervous Activity (SNA), present in several models of hypertension, can be a determining factor for the genesis and maintenance of the disease. Experimental and clinical studies show that attenuation of elevated SNA may cause an improvement in the prognosis of hypertensive patients, especially those of renovascular origin. Elucidating the mechanisms underlying the increase of SNA in renovascular hypertension may be of great value in understanding the etiology of the disease, and may even contribute to the elaboration of new therapeutic processes. Recent findings obtained in our laboratory point to a change in spinal circuitry in the model 2 kidneys - 1 clip (2K - 1C) of hypertension, especially a modification in glutamatergic and angiotensinergic pathways involved in the establishment of sympathetic pre - ganglionic activity for renal territory. However, the origin of such projections is not yet known. The present project aims to contribute to the knowledge about the role played by the Rostral Ventrolateral Medulla (RVLM) and paraventricular nucleus of the hypothalamus (PVN) on the establishment of high preganglionic activity in the 2k-1C model. In addition, we also intend to evaluate the involvement of such areas for elevated SNA during the course of renovascular hypertension. (AU)

Scientific publications

(9)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MILANEZ, MAYCON I. O.; SILVA, ADILSON M.; PERRY, JULIANA C.; FABER, JEAN; NISHI, ERIKA E.; BERGAMASCHI, CASSIA T.; CAMPOS, RUY R.. Pattern of sympathetic vasomotor activity induced by GABAergic inhibition in the brain and spinal cord. PHARMACOLOGICAL REPORTS, v. 72, n. 1, p. 67-79, FEB 2020. (18/01898-4, 18/02671-3)

MILANEZ, M. I. O.; LIBERATORE, A. M. A.; NISHI, E. E.; BERGAMASCHI, C. T.; CAMPOS, R. R.; KOH, I. H. J.. atterns of renal and splanchnic sympathetic vasomotor activity in an animal model of survival to experimental sepsi. Brazilian Journal of Medical and Biological Research, v. 55, n. 1, 2022. (17/21052-0, 18/02671-3, 18/01898-4)

MILANEZ, MAYCON I. O.; NISHI, ERIKA E.; ROCHA, ANTONIO A.; BERGAMASCHI, CASSIA T.; CAMPOS, RUY R.. Interaction between angiotensin II and GABA in the spinal cord regulates sympathetic vasomotor activity in Goldblatt hypertension. Neuroscience Letters, v. 728, MAY 29 2020. (18/02671-3, 18/01898-4)

MILANEZ, MAYCON I. O.; VEIGA, AMANDA C.; MARTINS, BEATRIZ S.; PONTES, ROBERTO B.; BERGAMASCHI, CASSIA T.; CAMPOS, RUY R.; NISHI, ERIKA E.. Renal Sensory Activity Regulates the gamma-Aminobutyric Acidergic Inputs to the Paraventricular Nucleus of the Hypothalamus in Goldblatt Hypertension. FRONTIERS IN PHYSIOLOGY, v. 11, DEC 15 2020. (17/03905-5, 20/02617-9, 18/02671-3, 18/01898-4, 18/11909-3, 15/23809-5)

MILANEZ, MAYCON I. O.; NISHI, ERIKA E.; MENDES, RODRIGO; ROCHA, ANTONIO A.; BERGAMASCHI, CASSIA T.; CAMPOS, RUY R.. Renal sympathetic activation triggered by the rostral ventrolateral medulla is dependent of spinal cord AT1 receptors in Goldblatt hypertensive rats. Peptides, v. 146, DEC 2021. (18/01898-4, 18/02671-3, 19/25295-0)

VEIGA, AMANDA C.; MILANEZ, MAYCON I. O.; CAMPOS, RUY R.; BERGAMASCHI, CASSIA T.; NISHI, ERIKA E.. The involvement of renal afferents in the maintenance of cardiorenal diseases. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, v. 320, n. 1, p. R88-R93, JAN 2021. (18/01898-4, 18/02671-3, 18/11909-3, 17/03905-5)

MILANEZ, MAYCON I. O.; MARTINS, GUSTAVO R.; NISHI, ERIKA E.; BERGAMASCHI, CASSIA T.; CAMPOS, RUY R.. Differential sympathetic vasomotor control by spinal AT(1) and V1 a receptors in the acute phase of hemorrhagic shock. European Journal of Pharmacology, v. 866, JAN 5 2020. (18/02671-3, 18/01898-4)

MILANEZ, MAYCON I. O.; NISHI, ERIKA E.; BERGAMASCHI, CASSIA T.; CAMPOS, RUY R.. Role of spinal neurons in the maintenance of elevated sympathetic activity: a novel therapeutic target?. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, v. 319, n. 3, p. 6-pg., 2020-09-01. (18/02671-3, 18/01898-4)

DE OLIVEIRA MILANEZ, MAYCON; NISHI, ERIKA; ROCHA, ANTONIO; BERGAMASCHI, CASSIA; CAMPOS, RUY. ROLE OF SPINAL AT1, IONOTROPIC GLUTAMATERGIC AND GABAERGIC RECEPTORS ON CONTROL OF RENAL SYMPATHETIC NERVE ACTIVITY IN 2K-1C RATS. FASEB JOURNAL, v. 34, p. 2-pg., 2020-04-01. (18/01898-4)