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Evaluation of brain-spinal projections in the temporal establishment of renal sympathetic hyperactivation in Renovascular Hypertension

Grant number: 18/01898-4
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): August 01, 2018
Effective date (End): January 31, 2022
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal researcher:Ruy Ribeiro de Campos Junior
Grantee:Maycon Igor de Oliveira Milanez
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil


The increase of the Sympathetic Nervous Activity (SNA), present in several models of hypertension, can be a determining factor for the genesis and maintenance of the disease. Experimental and clinical studies show that attenuation of elevated SNA may cause an improvement in the prognosis of hypertensive patients, especially those of renovascular origin. Elucidating the mechanisms underlying the increase of SNA in renovascular hypertension may be of great value in understanding the etiology of the disease, and may even contribute to the elaboration of new therapeutic processes. Recent findings obtained in our laboratory point to a change in spinal circuitry in the model 2 kidneys - 1 clip (2K - 1C) of hypertension, especially a modification in glutamatergic and angiotensinergic pathways involved in the establishment of sympathetic pre - ganglionic activity for renal territory. However, the origin of such projections is not yet known. The present project aims to contribute to the knowledge about the role played by the Rostral Ventrolateral Medulla (RVLM) and paraventricular nucleus of the hypothalamus (PVN) on the establishment of high preganglionic activity in the 2k-1C model. In addition, we also intend to evaluate the involvement of such areas for elevated SNA during the course of renovascular hypertension. (AU)

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Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VEIGA, AMANDA C.; MILANEZ, MAYCON I. O.; CAMPOS, RUY R.; BERGAMASCHI, CASSIA T.; NISHI, ERIKA E. The involvement of renal afferents in the maintenance of cardiorenal diseases. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, v. 320, n. 1, p. R88-R93, JAN 2021. Web of Science Citations: 0.
MILANEZ, MAYCON I. O.; VEIGA, AMANDA C.; MARTINS, BEATRIZ S.; PONTES, ROBERTO B.; BERGAMASCHI, CASSIA T.; CAMPOS, RUY R.; NISHI, ERIKA E. Renal Sensory Activity Regulates the gamma-Aminobutyric Acidergic Inputs to the Paraventricular Nucleus of the Hypothalamus in Goldblatt Hypertension. FRONTIERS IN PHYSIOLOGY, v. 11, DEC 15 2020. Web of Science Citations: 0.
MILANEZ, MAYCON I. O.; NISHI, ERIKA E.; ROCHA, ANTONIO A.; BERGAMASCHI, CASSIA T.; CAMPOS, RUY R. Interaction between angiotensin II and GABA in the spinal cord regulates sympathetic vasomotor activity in Goldblatt hypertension. Neuroscience Letters, v. 728, MAY 29 2020. Web of Science Citations: 0.
MILANEZ, MAYCON I. O.; SILVA, ADILSON M.; PERRY, JULIANA C.; FABER, JEAN; NISHI, ERIKA E.; BERGAMASCHI, CASSIA T.; CAMPOS, RUY R. Pattern of sympathetic vasomotor activity induced by GABAergic inhibition in the brain and spinal cord. PHARMACOLOGICAL REPORTS, v. 72, n. 1, p. 67-79, FEB 2020. Web of Science Citations: 1.
MILANEZ, MAYCON I. O.; MARTINS, GUSTAVO R.; NISHI, ERIKA E.; BERGAMASCHI, CASSIA T.; CAMPOS, RUY R. Differential sympathetic vasomotor control by spinal AT(1) and V1 a receptors in the acute phase of hemorrhagic shock. European Journal of Pharmacology, v. 866, JAN 5 2020. Web of Science Citations: 0.

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