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Evaluation of neurodevelopmental and behavioral profile in rats after brain insult in early life.

Grant number: 11/08719-9
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): June 01, 2011
Effective date (End): December 31, 2012
Field of knowledge:Health Sciences - Medicine
Principal researcher:Fulvio Alexandre Scorza
Grantee:Manaira Giraudon Monteiro Tobias
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

For the perfect function of neuronal circuitry, synaptic formation and specificity are of fundamental importance. With respect to synaptic function in the early stages of development, GABA has excitatory action due to high intracellular concentration of Cl-ions. In this context, neonatal seizures may occur more easily and therefore have serious consequences in the long term, may be a predisposing factor for epilepsy syndromes. It is therefore of fundamental importance to evaluate the long-term nervous system after status epilepticus (SE) neonatal. Thus, this project aims to analyze the short memories and long term (water maze), habituation (open field), and the quantitative expression of GABAergic synaptic adhesion molecules (neuroligin-2), glutamatergic (neuroligin-1 and PSD-95), co-transporter Na +-K + - 2Cl-(NKCC1) and co-transporter K +-Cl-(KCC2), conveyor of GABA (GABAT-1) and transporter of glutamate (EAAT-4) at different stages the life of neonatal rats subjected to SE (P9 extra uterine life).

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