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Chemical-pharmaceutical analysis, microbiological testing, study of dissolution and comparison of the antimicrobial agent doxycycline hyclate with its inclusion complex

Grant number: 10/12719-1
Support type:Scholarships in Brazil - Master
Effective date (Start): August 01, 2011
Effective date (End): February 29, 2012
Field of knowledge:Health Sciences - Pharmacy - Medicines Analysis and Control
Principal Investigator:Hérida Regina Nunes Salgado
Grantee:Ana Carolina Kogawa
Home Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil


The doxycycline hyclate is a broad-spectrum antibiotic derived from oxytetracycline used in several countries. It has been used to treat infectious diseases and as an additive in animal feed to facilitate their growth. In Brazil this drug is marketed by Union Chemical pharmaceutical dosage form in 80mg and 200mg tablets with the name Doxitrat ® and 10ml vial with the name Calmium ®, since 2004 the pill 100mg dosage form whose commercial name is Uni Doxycycline ® is out of line. This project aims to develop and validate analytical methodologies more dynamic of doxycycline hyclate, including spectrophotometric analysis, chromatographic and microbiological tests, compare the content and antimicrobial activity of doxycycline hyclate with their inclusion complex, conducting study of dissolution, as well as have qualitative identification techniques for the pharmaceutical form and raw material. (AU)

Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
KOGAWA, Ana Carolina. Análise químico-farmacêutica de hiclato de doxiciclina em comprimidos e de seu complexo de inclusão. 2012. 142 f. Master's Dissertation - Universidade Estadual Paulista "Júlio de Mesquita Filho" Faculdade de Ciencias Farmaceuticas. Araraquara.

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