Lead exposure in São Paulo: blood levels in preschool children and risk factors associated

• Grant number: 11/13076-0
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: January 01, 2012
• End date: December 31, 2013
• Field of knowledge: Health Sciences - Collective Health - Public Health
• Principal Investigator: Maria Regina Alves Cardoso
• Grantee: Kelly Polido Kaneshiro Olympio
• Host Institution: Faculdade de Saúde Pública (FSP). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Lead is broadly known as an ubiquitous and highly toxic metal to human health. In Brazil, there are scarce data on lead contamination among the general population, especially in the more vulnerable population composed by preschool children. The aims of this study are: a) to estimate the blood lead levels in children attending Day Care Centers (DCCs) from municipality of São Paulo; b) to correlate the blood lead levels with the location of DCCs and c) to analyze the association between high lead levels found in venous blood and risk factors present in the home and school settings. This study will include 26 DCCs, totalizing around 2,400 children aged 1-3 years. A questionnaire will be applied to parents or guardians to obtain socioeconomic and demographic information and investigating potential risk factors to lead contamination in children's homes. DCCs also will be checked and potential risk factors found will be registered in a specific form. Venous blood samples will be collected from all the study children, whose parents or guardians have signed the informed consent term, to estimate the lead concentrations. Venous blood samples will be analyzed by GF AAS. All the analysis will be performed in the Applied Spectrometry Laboratory (ASL) of the Chemistry Institute of the University of São Paulo and 10% of the blood samples will be analyzed by the Centers for Disease Control and Prevention for comparison between laboratories. Descriptive Statistics, correlation tests and Multiple Regression Analysis will be applied to data.

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

OLYMPIO, K. P. K.; FERREIRA, A. P. S. S.; RODRIGUES, M. H. C.; LUZ, M. S.; ALBUQUERQUE, L. G. R.; BARBOSA, JR F.; CARDOSO, M. R. A.; OLIVEIRA, V, P.; BUZALAF, M. A. R.. Are fingernail lead levels a reliable biomarker of lead internal dose?. JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, v. 62, DEC 2020. (16/11087-8, 11/13076-0)

KANESHIRO OLYMPIO, KELLY POLIDO; DA ROCHA SILVA, JULIA PRESTES; DA SILVA, AGNES SOARES; DE OLIVEIRA SOUZA, VANESSA CRISTINA; RABELO BUZALAF, MARILIA AFONSO; BARBOSA, JR., FERNANDO; ALVES CARDOSO, MARIA REGINA. Blood lead and cadmium levels in preschool children and associated risk factors in Sao Paulo, Brazil. Environmental Pollution, v. 240, p. 831-838, SEP 2018. (11/23272-0, 11/13076-0, 12/21840-4)

LEROUX, ISABELLE NOGUEIRA; DA SILVA FERREIRA, ANA PAULA SACONE; PANIZ, FERNANDA POLLO; PEDRON, TATIANA; SALLES, FERNANDA JUNQUEIRA; DA SILVA, FABIO FERREIRA; MALTEZ, HELOISA FRANCA; BATISTA, BRUNO LEMOS; KANESHIRO OLYMPIO, KELLY POLIDO. Lead, Cadmium, and Arsenic Bioaccessibility of 24 h Duplicate Diet Ingested by Preschool Children Attending Day Care Centers in Brazil. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, v. 15, n. 8, AUG 2018. (16/10060-9, 12/21840-4, 14/05151-0, 15/01395-4, 11/23272-0, 14/20945-2, 11/13076-0)

OLIVEIRA, A. S.; COSTA, E. A. C.; PEREIRA, E. C.; FREITAS, M. A. S.; FREIRE, B. M.; BATISTA, B. L.; LUZ, M. S.; OLYMPIO, K. P. K.. The applicability of fingernail lead and cadmium levels as subchronic exposure biomarkers for preschool children. Science of The Total Environment, v. 758, MAR 1 2021. (11/13076-0, 17/14392-9, 12/21840-4, 11/23272-0)