Effect of neural mobilization in neuropathic pain: evaluation of glial cells and nerve growth factor in the dorsal root ganglion

• Grant number: 11/08678-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): November 01, 2011
• Effective date (End): December 31, 2012
• Field of knowledge: Biological Sciences - Morphology - Anatomy
• Principal Investigator: Marucia Chacur
• Grantee: Joyce Teixeira da Silva
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Several studies demonstrate the involvement of glial cells and neurotrophins in neuropathic pain by modulating the response nociceptive. However, these mechanisms are poorly understood when discussed in the dorsal root ganglia of the spinal cord (DRG). In recent years increased studies related to the development of techniques for the treatment of neuropathic pain. Pain is characterized by spontaneous burning pain accompanied by allodynia and hyperalgesia. The technique of Neural Mobilization is non-invasive and clinically proven to be effective in reducing sensitivity to pain and therefore improving the quality of life of patients. It should be noted that this technique has been adapted to rats in our laboratory and is best described in the methodology of this project. Our aim is to characterize, through the methods of immunohistochemistry the involvement of satellite cells, GFAP (glial fibrillary acidic protein), and NGF (growth factor neural) in DRG of rats with chronic constrictive injury (CCI) of the sciatic nerve and treated with neural mobilization.(AU)