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Histologic evaluation of the smooth muscle of golden retriever dogs affected by progressive muscular dystrophy (GRMD).

Grant number: 11/18842-2
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): December 01, 2011
Effective date (End): November 30, 2012
Field of knowledge:Agronomical Sciences - Veterinary Medicine
Principal researcher:Maria Angelica Miglino
Grantee:Bruno Germano
Home Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Duchenne muscular dystrophy (DMD) is one of the most common inherited myopathies, recessive and is linked to chromosome X. It is a degenerative myopathy characterized by the absence or dysfunction of dystrophin, a muscle membrane protein.Dogs Golden Retriever muscular dystrophy (GRMD) represent the best animal models available for future therapeutic trials aimed at treatment of DMD in humans, due to the extensive homology between both pathogenicity.This project proposes the description of the histomorphological aspects of the smooth muscle of tubular organs of the gastrointestinal tract as well as bladder, ureters and blood vessels of dogs GRMDs, since the action of muscular dystrophy in striated skeletal muscle has been extensively studied, while action on the smooth muscle of this disease remains poorly understood. The results may be relevant to better understanding of action and disease progression in this muscle group, allowing the development of possible new approaches to treat the same, thus enabling a better quality of life of individuals affected by the disease.

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