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Effect of low concentrations of antineoplastic agents on peripheral human blood lymphocytes

Grant number: 11/20307-8
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): January 01, 2012
Effective date (End): December 31, 2012
Field of knowledge:Biological Sciences - Immunology - Cellular Immunology
Principal Investigator:Ramon Kaneno
Grantee:Fabiana Albani Zambuzi
Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil


Previous studies of our group have shown that low concentrations (non-toxic) of antineoplastic agents positively modulated dendritic cells, favoring their in-vitro maturation and improving their antigen presentation function. The effects on colorectal cancer cells were also investigated, and it was observed an increased immunogenicity and susceptibility to cytotoxic T lymphocytes. However, it has not been evaluated the effects of treatment on peripheral blood lymphocytes, key cells involved in antitumor resistance. Thereby, this study aims to investigate the effect of 5-fluorouracil and AZA, at minimum effective (MEC) and non-toxic (NTC) concentrations as previously determined for tumor cells, on lymphocytes of normal individuals. Initially we will investigate whether the selected doses have direct toxic activity on lymphocytes and then evaluate its effects on the proliferative activity of these cells.(AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SILVA-STENICO, MARIA ESTELA; KANENO, RAMON; ZAMBUZI, FABIANA ALBANI; VAZ, MARCELO G. M. V.; ALVARENGA, DANILLO O.; FIORE, MARLI FATIMA. Natural Products from Cyanobacteria with Antimicrobial and Antitumor Activity. CURRENT PHARMACEUTICAL BIOTECHNOLOGY, v. 14, n. 9, p. 820-828, . (09/05474-5, 10/18732-0, 11/20307-8, 11/08092-6, 10/09867-9)

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