Gene expression of different hormone receptors in orbital fibroblasts, undergo adipocytic differentiation in patients with Graves' ophthalmopathy

• Grant number: 11/18464-8
• Support type: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): February 01, 2012
• Effective date (End): January 31, 2013
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal researcher: Gláucia Maria Ferreira da Silva Mazeto
• Grantee: Sarah Santiloni Cury
• Home Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

The Graves 'ophthalmopathy (GO) constitutes one of the most striking manifestations of Graves' disease. Given the existence of dark spots on the genesis and treatment of OG, this project will evaluate the expression of PPAR-gama receptor, ER, AR, GR, TR, before and after treatment with glucocorticoids in orbital fibroblasts of patients with OG. For this, the fibroblasts, in pre-adipocytes taken from patients with GO, will be placed in culture and subsequently subjected to the method of adipocyte differentiation and treatment with glucocorticoids, with molecular analysis of gene expression of these receptors.

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CURY, SARAH SANTILONI; OLIVEIRA, MIRIANE; SIBIO, MARIA TERESA; CLARA, SUELI; MELO LUVIZOTTO, RENATA DE AZEVEDO; CONDE, SANDRO; JORGE, EDSON NACIB; NUNES, VANIA DOS SANTOS; NOGUEIRA, CELIA REGINA; FERREIRA DA SILVA MAZETO, GLAUCIA MARIA. Graves' ophthalmopathy: low-dose dexamethasone reduces retinoic acid receptor-alpha gene expression in orbital fibroblasts. ARCHIVES OF ENDOCRINOLOGY METABOLISM, v. 62, n. 3, p. 366-369, MAY-JUN 2018. Web of Science Citations: 0.

SARAH SANTILONI CURY; MIRIANE OLIVEIRA; MARIA TERESA SÍBIO; SUELI CLARA; RENATA DE AZEVEDO MELO LUVIZOTTO; SANDRO CONDE; EDSON NACIB JORGE; VANIA DOS SANTOS NUNES; CÉLIA REGINA NOGUEIRA; GLÁUCIA MARIA FERREIRA DA SILVA MAZETO. Graves’ ophthalmopathy: low-dose dexamethasone reduces retinoic acid receptor-alpha gene expression in orbital fibroblasts. ARCHIVES OF ENDOCRINOLOGY METABOLISM, v. 62, n. 3, p. -, Maio 2018.

Graves’ ophthalmopathy: low-dose dexamethasone reduces retinoic acid receptor-alpha gene expression in orbital fibroblasts. ARCHIVES OF ENDOCRINOLOGY METABOLISM, n. ahead, p. -, 2018.

SARAH SANTILONI CURY; MIRIANE OLIVEIRA; MARIA TERESA SÍBIO; SUELI CLARA; RENATA DE AZEVEDO MELO LUVIZOTTO; SANDRO CONDE; EDSON NACIB JORGE; VANIA DOS SANTOS NUNES; CÉLIA REGINA NOGUEIRA; GLÁUCIA MARIA FERREIRA DA SILVA MAZETO. Gene expression of estrogen receptor-alpha in orbital fibroblasts in Graves’ ophthalmopathy. ARCHIVES OF ENDOCRINOLOGY METABOLISM, v. 59, n. 3, p. -, Jun. 2015.

CURY, SARAH SANTILONI; OLIVEIRA, MIRIANE; SIBIO, MARIA TERESA; CLARA, SUELI; MELO LUVIZOTTO, RENATA DE AZEVEDO; CONDE, SANDRO; JORGE, EDSON NACIB; NUNES, VANIA DOS SANTOS; NOGUEIRA, CELIA REGINA; FERREIRA DA SILVA MAZETO, GLAUCIA MARIA. Gene expression of estrogen receptor-alpha in orbital fibroblasts in Graves' ophthalmopathy. Arquivos Brasileiros de Endocrinologia e Metabologia, v. 59, n. 3, p. 273-276, JUN 2015. Web of Science Citations: 4.

SARAH SANTILONI CURY; MIRIANE OLIVEIRA; MARIA TERESA SÍBIO; SUELI CLARA; RENATA DE AZEVEDO MELO LUVIZOTTO; SANDRO CONDE; EDSON NACIB JORGE; VANIA DOS SANTOS NUNES; CÉLIA REGINA NOGUEIRA; GLÁUCIA MARIA FERREIRA DA SILVA MAZETO. Graves ophthalmopathy: low-dose glucocorticoid increases peroxisome proliferator-activated receptor-gamma gene expression. Arquivos Brasileiros de Oftalmologia, v. 77, n. 5, p. -, Out. 2014.