Clinical, hematological profile, serum chemistry and urine of dogs with chronic kidney disease under treatment with Ketoanalogues (Ketosteril ®)

• Grant number: 11/18569-4
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: January 01, 2012
• End date: November 30, 2013
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
• Principal Investigator: Priscylla Tatiana Chalfun Guimaraes-Okamoto
• Grantee: Tácia Tavares de Aquinas
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Chronic kidney disease (CKD) is a common disorder in the clinic for small animals. Ketoanalogues amino acids are deaminated, and they do not contain nitrogen and do not generate nitrogen co-products, which have to be eliminated by the kidneys. It's still a little-used drug in veterinary medicine due to its high cost. This study aims to evaluate clinical and laboratory animals with CKD treated with Ketoanalogues, using a smaller dose than that suggested by the literature and assessment of the contribution of Ketoanalogues, with a smaller dose than that suggested by the literature, in the treatment of animals with CKD. The animals will be treated with a nutraceutical comprising essential amino acids and Ketoanalogues. Group I (control): animals submitted to conventional treatment for CKD and renal disease patients to commercial feed. Group II: animals submitted to conventional treatment for CKD, commercial diets for renal disease, and cetoanálogos at a dose of half a tablet for each 5kg, given every 24 hours for 30 days. Group III: animals submitted to conventional treatment for CKD, commercial diets for renal disease, and Ketoanalogues at a dose of half a tablet for each 5kg, given every 48 hours for 30 days. Will be conducted three clinical and laboratory evaluations, the first at the beginning of treatment, the second after 15 days of treatment, and the third 30 days after starting treatment. We will determine the hematological, and biochemical profile (creatinine, urea, albumin, calcium, phosphorus, sodium, and potassium). Urinalysis will be performed to check the protein and the protein-to-creatinine ratio.(AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LIGUORI, TACIA T. A.; MELCHERT, ALESSANDRA; TAKAHIRA, REGINA K.; RAMOS, PAULO R. R.; PADOVANI, CARLOS R.; BARRETTI, PASQUAL; GUIMARAES-OKAMOTO, PRISCYLLA T. C.. Randomized controlled clinical trial of ketoanalogues supplementation in dogs with chronic kidney disease. Pesquisa Veterinária Brasileira, v. 38, n. 3, p. 489-495, MAR 2018. (11/18569-4)

LIGUORI, TACIA T. A.; MELCHERT, ALESSANDRA; TAKAHIRA, REGINA K.; RAMOS, PAULO R. R.; PADOVANI, CARLOS R.; BARRETTI, PASQUAL; GUIMARAES-OKAMOTO, PRISCYLLA T. C.. Randomized controlled clinical trial of ketoanalogues supplementation in dogs with chronic kidney disease. Pesquisa Veterinária Brasileira, v. 38, n. 3, p. 7-pg., 2018-03-01. (11/18569-4)