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Effects of exercise training in concentrations of inflammatory biomarkers and cognitive functions in patients with Alzheimer's Disease

Grant number: 11/04767-9
Support type:Scholarships in Brazil - Master
Effective date (Start): March 01, 2012
Effective date (End): August 31, 2013
Field of knowledge:Health Sciences - Physical Education
Principal Investigator:Florindo Stella
Grantee:Marcelo Garuffi Santos
Home Institution: Instituto de Biociências (IB). Universidade Estadual Paulista (UNESP). Campus de Rio Claro. Rio Claro , SP, Brazil


Alzheimer's disease (AD) is a neurodegenerative process, high prevalence in the population. The analysis of biomarkers is a device well suited to understand and study the causes and prevention methods of this disease. Non-pharmacological interventions, such as physical exercise, are also recommended to avoid the decline of the disease, improving cognitive functions and functionality of the patient. The present study aims to evaluate the effects of an aerobic exercise program on plasma concentrations of inflammatory biomarkers and cognitive functions in patients with Alzheimer's disease. The sample consists of 40 patients with AD divided into two groups: a) Training Group (WG) composed of 20 patients with AD who will participate in a program of physical exercise regular and systematic, three times a week, lasting 60 minutes each session for 4 months; b) Social Gathering Group (SCG) consists of 20 other patients who did not participate in this or any other motor intervention program. The participants will conduct pre-and post trial period, through questionnaires, blood and motor tests The data will be treated by descriptive procedures, checking for their distribution through the Shapiro Wilk. For normal data will be used one-way ANOVA, two-way ANOVA and Pearson correlation. For non-normal data will be performed U Mann Whitney test, Wilcoxon test and Spearman correlation, assuming a significance level of 5% for all analysis.

Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SANTOS, Marcelo Garuffi. Efeitos do exercício físico multimodal nas concentrações plasmáticas de biomarcadores, funções cognitivas e funcionalidade em pacientes com doença de Alzheimer. 2013. 94 f. Master's Dissertation - Universidade Estadual Paulista "Júlio de Mesquita Filho" Instituto de Biociências (Campus de Rio Claro)..

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