Association between polymorphisms in genes encoding pro- and anti oxidants proteins and the susceptibility to nephropathy in French cohorts of type 1 diabetic patients: Validation of results observed in a Brazilian series.

• Grant number: 11/15015-8
• Support Opportunities: Scholarships in Brazil - Master
• Start date: April 01, 2012
• End date: June 30, 2014
• Field of knowledge: Biological Sciences - Genetics - Human and Medical Genetics
• Principal Investigator: Maria Lucia Cardillo Corrêa Giannella
• Grantee: Thiago Andrade Patente
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated scholarship(s): 13/04002-8 - Oxidative stress and renal complications in Diabetes Mellitus: implications of genetic variants in CYBA, SOD3, CAT and GPX4 genes, BE.EP.MS

Abstract

Evidences suggest that a genetic predisposition determines susceptibility to chronic complications of diabetes mellitus (DM), along with chronic hyperglycemia, hypertension and dyslipidemia. Since oxidative stress has been recognized as the final element of common biochemical pathways induced by hyperglycemia, the genes that encode pro-and antioxidant enzymes are candidates to confer susceptibility to complications. A study conducted in our laboratory demonstrated the association between several polymorphisms (some of them functional) in the promoter region or the 3'UTR of genes encoding enzymes of pro-oxidant systems (NOX-2 and p22phox) and antioxidants (GCLC, GPX-4, TXNRD2 and TXN) and risk for the presence of diabetic nephropathy in type 1 DM of long duration recruited patients in different diabetes services in the Southeast and Southern Brazil. This project aims to extend this study, validating the association between the presence of diabetic nephropathy and these candidates polymorphisms in three French cohort of patients with type 1 DM (SURGENE cohort [n = 340]; GENEDIAB cohort [n = 494] and GENESIS cohort [n = 501]). Replicating results of an association between a SNP and a phenotypic trait in cohorts of patients from different geographic origins, increases the participation of that SNP and can improve understanding about its biological significance.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MOHAMMEDI, KAMEL; PATENTE, THIAGO A.; BELLILI-MUNOZ, NAIEMA; DRISS, FATHI; MONTEIRO, MARIA BEATRIZ; ROUSSEL, RONAN; PAVIN, ELIZABETH J.; SETA, NATHALIE; FUMERON, FREDERIC; AZEVEDO, MIRELA J.; et al. Catalase activity, allelic variations in the catalase gene and risk of kidney complications in patients with type 1 diabetes. Diabetologia, v. 56, n. 12, p. 2733-2742, DEC 2013. (11/15015-8)

MONTEIRO, M. B.; PATENTE, T. A.; MOHAMMEDI, K.; QUEIROZ, M. S.; AZEVEDO, M. J.; CANANI, L. H.; PARISI, M. C.; MARRE, M.; VELHO, G.; CORREA-GIANNELLA, M. L.. Sex-specific associations of variants in regulatory regions of NADPH oxidase-2 (CYBB) and glutathione peroxidase 4 (GPX4) genes with kidney disease in type 1 diabetes. Free Radical Research, v. 47, n. 10, p. 804-810, OCT 2013. (11/15015-8, 09/09276-3, 09/04162-0)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

PATENTE, Thiago Andrade. Association of single nucleotide polymorphisms in the genes GPX4, CYBB, CYBA, CAT e SLC2A2 and the susceptibility to chronic kidney disease in Brazilian and French cohorts of type 1 diabetes mellitus patients. 2014. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.