Role of complement component C5 to in vivo leptospirose control in murine models

• Grant number: 11/15733-8
• Support Opportunities: Scholarships in Brazil - Master
• Start date: March 01, 2012
• End date: December 31, 2013
• Field of knowledge: Biological Sciences - Immunology
• Principal Investigator: Lourdes Isaac
• Grantee: Iris Arantes de Castro
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 10/50043-0 - Complement system and pathogenicity of Leptospires: mechanisms of activation and evasion, identification of bacterial ligands, characterization of proteases and establishment of an in vivo murine model, AP.TEM

Abstract

Rodents are considered resistent to leptospirosis while hamsters and guinea pig are suscetible. Few studies investigated the immune mechanisms that are triggered during this infection.ADLER & FAINE (1976) demonstrated that this resistance is dependent on acquired immune response since cyclophosphamide treated mice became suscetible to this infection by L. interrogans sorovar Pomona. Other researchers showed that C3H/SCID mice carrying severe combined immunodeficiency die after injection of L. interrogans sorovar Copenhageni.Considering that the complement system is crucial to elimination of this pathogen we will investigate if C5 deficient mice are more susceptible to infection by Leptospira interrogans sorovar Pomona isolado Fromm. We will use A/J e DBA (C5 deficient) e C57 Black/6 e Balb/c (C5 suficient)mice to study this infection in vivo. So far there is no study that investigate the real role of the complement system to this infection in vivo.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BAVIA, LORENA; DE CASTRO, IRIS A.; AMANO, MARIANE TAMI; GONCALVES DA SILVA, ANA MARIA; VASCONCELLOS, SILVIO ARRUDA; ISAAC, LOURDES. Cytokine Profile in Early Infection by Leptospira interrogans in A/J Mice. JOURNAL OF IMMUNOLOGY RESEARCH, v. 2019, OCT 7 2019. (11/15733-8, 10/50043-0)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

CASTRO, Iris Arantes de. Role of complement component C5 to in vivo leptospirose control in murine models.. 2014. Master's Dissertation - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.