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Identification of non-coding RNAs expressed in the olfactory epithelium

Grant number: 11/22611-6
Support type:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): March 01, 2012
Effective date (End): February 28, 2017
Field of knowledge:Biological Sciences - Biochemistry - Molecular Biology
Principal researcher:Bettina Malnic
Grantee:João Batista Placido do Nascimento
Home Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:07/50743-9 - G protein coupled receptors and chemosensation, AP.TEM


Mammals can discriminate a vast number of odorants through their sense of smell. In the nasal cavity there are millions of olfactory sensory neurons, which are involved in this task. Odorants activate odorant receptors expressed in the cilia of olfactory neurons. The Odorant Receptors (ORs) belong to the GPCR superfamily and constitute a large gene family composed of around 1000 members in mice. Each olfactory neuron expresses one single type of OR gene, while the remaining OR genes remain silent. In this project we plan to investigate wether non codig RNAs are involved in the regulation of OR gene expression. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CAMARGO, ANTONIO P.; NAKAHARA, THIAGO S.; FIRMINO, LUIZ E. R.; NETTO, PAULO H. M.; DO NASCIMENTO, JOAO B. P.; DONNARD, ELISA R.; GALANTE, PEDRO A. F.; CARAZZOLLE, MARCELO F.; MALNIC, BETTINA; PAPES, FABIO. Uncovering the mouse olfactory long non-coding transcriptome with a novel machine-learning model. DNA Research, v. 26, n. 4, p. 365-378, . (11/22611-6, 16/24471-0, 18/11860-4, 16/05379-6, 13/08293-7, 15/50371-0)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
NASCIMENTO, João Batista Placido do. Identification of noncoding RNAs expressed in the olfactory epithelium. 2018. Doctoral Thesis - Universidade de São Paulo (USP). Conjunto das Químicas (IQ e FCF) (CQ/DBDCQ) São Paulo.

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