Effects of catecholamines on fluid replacement and its impact on the autonomic nervous system in rabbits: a study by spectral analysis

• Grant number: 11/22839-7
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: March 01, 2012
• End date: December 31, 2012
• Field of knowledge: Health Sciences - Medicine - Surgery
• Principal Investigator: Luiz Antonio Vane
• Grantee: Ana Beatriz Maringolo Pioltini
• Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Studying the effects of different catecholamines on fluid replacement of large volumes of physiological solutions on vascular retention, urine output, and HRV in animals subjected to hemorrhage. Objective: is to check the effects of different catecholamines on the volume expansion and the autonomic nervous system in rabbits submitted to hemorrhage. Check intravascular crystalloid retention associated with catecholamine ± and ² agonists in rabbits submitted to hemorrhage. Studying the behavior of the Heart Rate Variability by spectral analysis during volume replacement with crystalloids associated with catecholamine ± and ² agonists. Material and methods: the study will be used 24 rabbits, 12 males, race of Botucatu genetic group, with weights ranging from 2.5 to 4.5 kg provided by the Central Animal Facility of UNESP-Campus de Botucatu (SP). The study protocol was previously submitted to and approved by the Ethics Committee on Animal Experimentation of the Faculty of Medicine of Botucatu, Universidade Estadual Paulista "Júlio de Mesquita Filho".(AU)