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Impact of volume resuscitation on heart rate variability in a hemorragic shock model

Grant number: 12/00439-0
Support Opportunities:Regular Research Grants
Duration: May 01, 2012 - April 30, 2014
Field of knowledge:Health Sciences - Medicine - Surgery
Principal Investigator:José Otávio Costa Auler Junior
Grantee:José Otávio Costa Auler Junior
Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated researchers:Denise Aya Otsuki


Monitoring of volume status in trauma/hemorrhage patients based on conventional vital signs (heart rate, blood pressure and hemoglobin saturation) is complex and some of the alterations are present only at late, decompensated stage. Compensatory response to hemorrhage is affected by sympathetic and parasympathetic nervous system. The development of non-invasive assessment that would be capable of detecting early autonomic and hemodynamic compensatory responses have been sought in order to advance the diagnostic and therapeutic efforts, before the onset of autonomic and cardiovascular decompensation. Although heart rate alone is not very sensitive or specific in detecting hypotension, heart rate variability (HRV) provides some information about the autonomic control of the cardiovascular system.The aim of this study is to evaluate the effects experimental hemorrhage and resuscitation with crystalloid solution on the autonomic nervous activity, through indirect measures of HRV (LF/HF, HF). To this end, 16 crossbred Landrace x Large White pigs will be subjected to experimental hemorrhagic shock (60% volemia) and evaluated during 60 minutes without volume replacement. After that period, surviving animals will be submitted to volume resuscitation with Ringer's lactated solution and evaluated during 180 minutes. The hypothesis to be investigated is whether there is a positive correlation between measures of HRV and the progression of hemorrhagic shock or fluid replacement, so it may be used as an early predictor of survival in cases of severe hemorrhage. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SALOMAO, JR., EDGARD; OTSUKI, DENISE AYA; CORREA, ANDRE LUIS; FANTONI, DENISE TABACCHI; DOS SANTOS, FERNANDO; IRIGOYEN, MARIA CLAUDIA; COSTA AULER, JR., JOSE OTAVIO. Heart Rate Variability Analysis in an Experimental Model of Hemorrhagic Shock and Resuscitation in Pigs. PLoS One, v. 10, n. 8, . (12/00439-0)

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