Evaluation of the potential antimicrobial, atiinflamatory, bone remodeling, antioxidant and anticancer of Malva sylvestris.

• Grant number: 11/23980-5
• Support Opportunities: Scholarships in Brazil - Doctorate
• Effective date (Start): March 01, 2012
• Effective date (End): February 25, 2016
• Field of knowledge: Health Sciences - Dentistry - Social and Preventive Dentistry
• Principal Investigator: Pedro Luiz Rosalen
• Grantee: Bruna Benso
• Host Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil

Abstract

For centuries the treatment plants was the only resource available to different ethnic groups for the prevention and treatment of many diseases. However, the indiscriminate use of plants without any knowledge phytochemical, pharmacological and toxicological issues is of great concern to health. The Malva sylvestris (Malvaceae plant family, known popularly as Malva-cheirosa/Malva-grande and Malva-silvestre) is cited in the literature as ethnopharmacological medication with anti-inflammatory, antimicrobial, healing and others. Thus, M. sylvestris presents empirical indications in dentistry (eg treatment of gingivitis, periodontal disease, stomatitis, etc.) and medicine (eg pharyngitis, bronchitis, healing processes, etc.). Although M. sylvestris has a large popular usage, the current scientific literature is scarce on information that support the biological properties attributed to this plant (especially in relation to its use in dentistry). Thus, this project aims to evaluate the pharmacological potential of M. sylvestris and four chemical fractions on biological activities of dental interest. Methodologies in vitro and in vivo will be conducted to assess the following effects of ethanolic extract of M. sylvestris (MES) and chemical fractions with different polarities (hexane, chloroform, ethyl acetate and aqueous): 1) Citototoxidade, 2) Antimicrobial, 3) Anti-inflammatory, 4) bone remodeling, 5) Activity of matrix metalloproteinase inhibition, 6 ) Antioxidant and 7) Antineoplastic. The results will be initially submitted to an exploratory analysis to determine the best statistical test, and then applied the test more convenient for each analysis presented in the work. In the end, is expected to determine the pharmacological potential of M. sylvestris (MES and fractions), thus providing a basis for the clinical use of this plant, and at the same time, a guide to the isolation and identification (s) principle (s) active (s) responsible (s) for each activity biological detected.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BENSO, BRUNA; FRANCHIN, MARCELO; MASSARIOLI, ADNA PRADO; RIZZATO PASCHOAL, JONAS AUGUSTO; ALENCAR, SEVERINO MATIAS; NOBRE FRANCO, GILSON CESAR; ROSALEN, PEDRO LUIZ. Anti-Inflammatory, Anti-Osteoclastogenic and Antioxidant Effects of Malva sylvestris Extract and Fractions: In Vitro and In Vivo Studies. PLoS One, v. 11, n. 9, SEP 19 2016. (11/23980-5)

BENSO, BRUNA; ROSALEN, PEDRO LUIZ; PASETTO, SILVANA; SALOME MARQUEZIN, MARIA CAROLINA; FREITAS-BLANCO, VERONICA; MURATA, RAMIRO MENDONCA. Malva sylvestris derivatives as inhibitors of HIV-1 BaL infection. NATURAL PRODUCT RESEARCH, v. 35, n. 6, p. 1064-1069, MAR 19 2021. (11/23980-5)

BENSO, BRUNA; ROSALEN, PEDRO LUIZ; ALENCAR, SEVERINO MATIAS; MURATA, RAMIRO MENDONCA. Malva sylvestris Inhibits Inflammatory Response in Oral Human Cells. An In Vitro Infection Model. PLoS One, v. 10, n. 10, OCT 19 2015. (11/23980-5)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

BENSO, Bruna. Evaluation of the antibacterial, anti-inflammatory, anti-osteoclastogenic and anti-HIV activities of Malva sylvestris. 2016. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Faculdade de Odontologia de Piracicaba Piracicaba, SP.