Neurotoxicity of manganese species mixtures

• Grant number: 12/04726-3
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: May 01, 2012
• End date: April 30, 2013
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
• Principal Investigator: Raúl Bonne Hernández
• Grantee: Mary Ishimine Nishita
• Host Institution: Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF). Universidade Federal de São Paulo (UNIFESP). Campus Diadema. Diadema , SP, Brazil

Abstract

The Mn and their species are associated with others chemical species in both environment and physiological level. Toxicologically, these interactions can lead to synergistic, additives or an antagonistic effect, which are not always well known and has received little attention. Indeed, the traditional in vitro or in vivo experiments for risk assessment about Mn development neurotoxicity and their mechanisms of action, are almost always conducted with isolated compounds. Although these studies are sorely needed, for the understanding of toxicological mechanisms of action this metal, new studies must to consider the interactions between different Mn species, which will be the aim this project. (AU)