Regulation of FASL gene expression by PGE2 in CD4+ T lymphocytes: role of transcriptional repressor ICER

• Grant number: 11/16115-6
• Support Opportunities: Scholarships in Brazil - Master
• Start date: April 01, 2012
• End date: December 31, 2013
• Field of knowledge: Biological Sciences - Immunology - Cellular Immunology
• Principal Investigator: João Gustavo Pessini Amarante Mendes
• Grantee: Cristiane Naffah de Souza
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

CD4+ T lymphocytes are responsible for orchestrating adaptive immune responses, helping macrophages, CD8+ T lymphocytes and B cells providing a more effective response against a foreign antigen. A typical adaptive immune response is characterized by a multistep process: antigen presenting to T lymphocytes by APCs (antigen-presenting cells), T lymphocytes activation and clonal expansion, differentiation of activated T cells in effector and memory cells, and cell death to maintain T cell population homeostasis. Elimination of T cells during the termination phase of an immune response occurs by apoptosis through AICD and ACAD. AICD occurs by death receptor FAS interacting with FASL. Our research group demonstrated that PGE2, produced by APCs during antigen presentation, leads to an inhibitory effect on FASL in CD4+ T-cell hybridoma, suppressing AICD in these cells. Therefore, our aim is to investigate the molecular mechanism by which PGE2 inhibits FASL expression, analyzing transcriptional factors involved in its expression.

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

SOUZA, Cristiane Naffah de. Regulation of FASL gene expression by PGE2 in CD4+ T lymphocytes: role of transcriptional repressor ICER.. 2014. Master's Dissertation - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.