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Use of beta-acids of hops (Humulus lupulus) in weanling pig diets

Grant number: 12/01005-3
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): April 01, 2012
Effective date (End): February 27, 2014
Field of knowledge:Agronomical Sciences - Animal Husbandry - Animal Nutrition and Feeding
Principal researcher:Valdomiro Shigueru Miyada
Grantee:Maicon Sbardella
Home Institution: Escola Superior de Agricultura Luiz de Queiroz (ESALQ). Universidade de São Paulo (USP). Piracicaba , SP, Brazil


The use of sub-therapeutic levels of antimicrobial agents in feed is an effective strategy for maintaining the gastrointestinal tract conditions and to improve the performance of weanling pigs. However, their use as feed additive has been restricted due to the possibility of development of bacterial cross-resistance. The purpose of this research is to study the potential of beta-acids of hops (Humulus lupulus) as replacement for antimicrobial growth promoters in weanling pig diets. The effects of beta-acids in weanling pig diets will be evaluated by an acceptability assay and an experiment to evaluate animal performance, nutrients digestibility, diarrhea frequency, intestinal epithelium structure (villus height, crypt depth, lamina propria thickness, muscular tunic thickness and number of goblet cells), oxidative metabolism of the intestine and meat (lipid oxidation and physical-chemical analysis of meat), organ morphometry (digestive organs and spleen) and intestinal microbiota, compared to an usual antimicrobial growth promoter, and a "minimum inhibitory concentration" assay of beta-acids of hops. The results of this study may provide important information on the potential use of beta-acids as a substitute of antimicrobial growth promoters in weanling pig diets.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SBARDELLA, MAICON; RACANICCI, ALINE M. C.; GOIS, FRANZ D.; DE LIMA, CRISTIANE B.; MIGOTTO, DANNIELLE L.; COSTA, LEANDRO B.; MIYADA, VALDOMIRO S. Effects of dietary hop (Humulus lupulus L.) -acids on quality attributes, composition and oxidative stability of pork meat. Journal of the Science of Food and Agriculture, v. 98, n. 6, p. 2385-2392, APR 2018. Web of Science Citations: 1.
SBARDELLA, M.; PERINA, D. P.; ANDRADE, C.; SANTOS, C. B.; CAIRO, P. L. G.; MARQUES, E. L. S.; REZENDE, R. P.; COSTA, L. B.; MIYADA, V. S. Effects of dietary hop beta-acids or colistin on the performance, nutrient digestibility, and intestinal health of weanling pigs. ANIMAL FEED SCIENCE AND TECHNOLOGY, v. 217, p. 67-75, JUL 2016. Web of Science Citations: 4.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SBARDELLA, Maicon. Use of β-acids of hops (Humulus lupulus) in weanling pig diets. 2015. Doctoral Thesis - Universidade de São Paulo (USP). Escola Superior de Agricultura Luiz de Queiroz (ESALA/BC) Piracicaba.

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