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Adjuvant effects of Escherichia coli thermo-labile toxin (LT1) derivatives in the specific antibody response directed to the E glycoprotein domain III of type 2 dengue virus (DENV2).

Grant number: 11/12751-5
Support type:Scholarships in Brazil - Master
Effective date (Start): June 01, 2012
Effective date (End): May 31, 2014
Field of knowledge:Biological Sciences - Parasitology
Principal researcher:Luis Carlos de Souza Ferreira
Grantee:Denicar Lina Nascimento Fabris
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

AbstractThe heat-labile toxins (LT) produced by enterotoxigenic Escherichia coli (ETEC) strains are, together with the cholera toxin (CT), some of the most studied mucosal adjuvants focusing both their academic interest and their potential use in applied areas of vaccine development. Although there are several reports describing the LT´s immunological activities, so far there are several gaps in the knowledge of these bacterial products that could permit more rational and appropriate use in vaccine formulations. The present project aims to evaluate the immunomodulatory properties of LT and some nontoxic derivatives (LT1-K63 and LT1-B) with regard to the specific serum antibody response elicited in parenterally vaccinated mice, particularly, regarding the glycosylation pattern of the immunoglobulin chains and how such patterns might affect some immunological features of these molecules. As a model antigen, a fragment of the type 2 dengue virus capsid protein (domain III of protein E) will be used. The present study shall contribute for the development of effective vaccine formulations against this pathogen.

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
FABRIS, Denicar Lina Nascimento. Adjuvant effects of Escherichia coli thermo-labile toxin (LT1) derivatives in the specific antibody response directed to the E glycoprotein domain III of type 2 dengue virus (DENV2).. 2014. Master's Dissertation - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.

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