Signaling pathways evaluation of the transcription factor NFkB activated by TNF-a in a model of protein deficiency

• Grant number: 11/14247-2
• Support Opportunities: Scholarships in Brazil - Master
• Start date: June 01, 2012
• End date: August 31, 2013
• Field of knowledge: Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
• Principal Investigator: Ricardo Ambrósio Fock
• Grantee: Dalila Cunha de Oliveira
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

TNF-alpha is a cytokine that participates in a wide range of biological activities including inflammation, growing, differentiation and apoptosis and is still able to regulate the expression of other cytokines. TNF-alpha shows its effects by binding to two distinct receptors, TNFR1 and TNFR2, once the receptor activation via TNFR1 is responsible for most of TNF-alpha effects, triggering a pathway of intracellular events that result in the activation of two transcription factors such as NFkB and c-Jun. Studies from our group has shown that malnutrition may alter the production of inflammatory cytokines such as IL-1, IL-6, TNF-alpha. Malnourished animals show an impaired of important receptors for NFkB activation pathway mediated by LPS. Thus we propose in this project to evaluate the signaling pathway of TNF-alfa and its importance for transcription factor NFkB activation in a model protein-energy malnutrition. (AU)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

OLIVEIRA, Dalila Cunha de. Evaluation of the transcription factor NFκB signaling pathway activated by TNF-α in a protein malnutrition model. 2013. Master's Dissertation - Universidade de São Paulo (USP). Conjunto das Químicas (IQ e FCF) (CQ/DBDCQ) São Paulo.