Study of Heck Arilation applying Arenediazonium Salts in the synthesis of hydroxy stilbenos and derivatives.

• Grant number: 12/07461-0
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: July 01, 2012
• End date: March 26, 2014
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Carlos Roque Duarte Correia
• Grantee: Carla Cristina Perez
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

This project aims at an interdisciplinary between organic synthesis, the biology, statistical and physical-chemistry methods. The main objective of this work is to find optimal conditions for the preparation of stilbene derivatives using the Heck Reaction as the key step. Thus, in order to expand the use of arenediazonium salts in obtaining stilbene derivatives, as well as evaluating the factors involved in this type of reaction, we are going to use Chemometrics as the main tool, in order to search for the optimum condition to obtain stilbenes. These results should be used to scale up the synthetic route. With the acquisition of large quantities of these compounds we are going to test the biological activity of those in collaboration with Professor Dr. Hiroshi Aoyama (IB/Unicamp). We intend to evaluate the pharmacological activities of some resveratrol and DMU-212 analogues. The optimized conditions should also be instrumental in the study of the reaction mechanism using MS (ESI).

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PEREZ, CARLA CRISTINA; PENA, JESUS MARCELO; DUARTE CORREIA, CARLOS ROQUE. Improved synthesis of bioactive stilbene derivatives applying design of experiments to the Heck-Matsuda reaction. NEW JOURNAL OF CHEMISTRY, v. 38, n. 8, p. 3933-3938, AUG 2014. (11/23832-6, 12/07461-0)