Assessing the effect of synthetic sweat on cotton fabric dyed with Indigo dye Vat blue 1, using chromatographic techniques and mass spectrometry

• Grant number: 12/08260-9
• Support Opportunities: Scholarships abroad - Research Internship - Master's degree
• Start date: August 01, 2012
• End date: January 31, 2013
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
• Principal Investigator: Maria Valnice Boldrin
• Grantee: Tuane Cristina dos Santos
• Supervisor: Harold S. Freeman
• Host Institution: Instituto de Química (IQ). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
• Institution abroad: North Carolina State University (NC State), United States
• Associated to the scholarship: 11/16056-0 - Assessment of the photochemical degradation of a food dye and of the removal of textile dyes from cotton fabric promoted by artificial sweat, using chromatographic techniques., BP.MS

Abstract

This project aims to investigate the effect of synthetic sweat on VAT dyes released from cotton fabric. To achieve this goal we intend to evaluate the leaching degree of the indigo dye CI VAT Blue 1, from the cotton fabric, under effect of synthetic sweat. We also intend to identify and quantify the by-products and the possible structural modifications occurred due this process, using chromatographic techniques: HPLC-DAD and LC-MS/MS. These studies will be complemented by correlating chemical structure and toxicological/mutagenic results (Ames test), contributing to the understanding of allergic and metabolic important reactions of dyes in the human body. (AU)