Comparative analysis of placental lesions in early- and late-onset preeclampsia

• Grant number: 12/08476-1
• Support Opportunities: Scholarships abroad - Research Internship - Master's degree
• Start date: August 01, 2012
• End date: August 31, 2012
• Field of knowledge: Health Sciences - Medicine - Maternal and Child Health
• Principal Investigator: Maria Terezinha Serrão Peraçoli
• Grantee: Ingrid Cristina Weel
• Supervisor: Steven S. Witkin
• Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
• Institution abroad: Cornell University, United States
• Associated to the scholarship: 10/12892-5 - Immunohistochemical analysis of cytokines and pro-and anti-angiogenic factors in placenta of pregnant women with pre-eclampsia., BP.MS

Abstract

Preeclampsia is a pregnancy-specific syndrome of humans, characterized by the appearance of hypertension and proteinuria after the 20th week of gestation. It is accepted that this disease originates in the placenta, probably due to factors involved in its formation and development. This project aims: a) to evaluate the histopathological lesions in placenta of pregnant women with PE comparing with normotensive pregnant women; b) to compare the frequency of newborns with intrauterine growth restriction between the groups of the women studied. Pregnant women with preeclampsia were classified according to the appearance of clinical symptoms in early-onset preeclampsia (<34 weeks gestation) and late-onset preeclampsia (e 34 weeks gestation). One hundred and forty pregnant women were selected, being 20 normotensive, 40 with early-onset PE and 80 with late-onset PE. A fragment of placenta was obtained immediately after delivery and prepared for histopathological analysis. The histological sections of 4 um-thick were placed on slides and staining with hematoxylin and eosin (HE). (AU)