Vaccination against hepatitis A in shift workers: evaluation of the humoral and cellular immune response

• Grant number: 11/20316-7
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: January 01, 2013
• End date: April 30, 2016
• Field of knowledge: Biological Sciences - Immunology - Cellular Immunology
• Principal Investigator: Marco Túlio de Mello
• Grantee: Francieli Ruiz da Silva
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

Sleep regulates immune functions. In this sense, we asked whether shift workers (morning, afternoon or night) vaccinated against hepatitis A would have some humoral and cellular response impairment. Men (18 to 55 years) will be recruited through different forms of media (electronic, newspapers, radio and magazines). The shift workers sleep pattern will be recorded polysomnographically. Subsequently, the volunteers will be underwent vaccination against hepatitis A (2 doses). After the first administration, blood samples will be collected at 30, 60 and 90 days to assess the humoral response in the experimental groups. The hormones prolactina, growth hormone, cortisol, adrenaline and noradrenaline will also be evaluated. Indeed, stimulations in vitro will be conducted to assess the cellular response profile against the vaccination through the production assessment of IL-4, IFNgama, IL-2 and TNFalfa. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

RUIZ, FRANCIELI S.; ROSA, DANIELA S.; ZIMBERG, IONA Z.; DOS SANTOS QUARESMA, MARCUS V. L.; NUNES, JETHE O. F.; APOSTOLICO, JULIANA S.; WECKX, LILY Y.; SOUZA, ALESSANDRA R.; NARCISO, FERNANDA V.; FERNANDES-JUNIOR, SILVIO A.; et al. Night shift work and immune response to the meningococcal conjugate vaccine in healthy workers: a proof of concept study. Sleep Medicine, v. 75, p. 263-275, NOV 2020. (12/09700-2, 11/20316-7)

RUIZ, F. S.; ROSA, D. S.; ZIMBERG, I. Z.; SANTOS, M., V; NUNES, J. O.; APOSTOLICO, J. S.; WECKX, L. Y.; SOUZA, A. R.; NARCISO, F., V; FERNANDES-JUNIOR, S. A.; et al. AWAKE WITH THE ENEMY - VACCINATION RESPONSE IS REDUCED BY NOCTURNAL SHIFT WORK. Sleep, v. 40, p. 2-pg., 2017-04-01. (12/09700-2, 11/20316-7)