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Evaluation of the toxicity of congeners 47 and 99 of polybrominated biphenyls (PBDEs) using mitochondrial assays.

Grant number: 12/04542-0
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): August 01, 2012
Effective date (End): January 31, 2014
Field of knowledge:Health Sciences - Pharmacy - Toxicological Analysis
Principal Investigator:Daniel Junqueira Dorta
Grantee:Murilo Pazin Silva
Host Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:09/06912-6 - Assessment of mitochondrial and cellular changes induced by representatives of major classes of poly-brominated biphenyls (PBDEs), AP.JP


The brominated flame retardants (highlighting polybrominated diphenyl ethers), are substances widely used in various consumer goods to increase their fire resistance and / or higher temperatures in case of fire, they reduce the spread of fire in interfering combustion of materials, thus increasing the chances of escape and reducing the severity of burns. The efficient control of the flame spread and low cost makes the polybrominated diphenyl ethers (PBDEs) the class is used for this purpose. These compounds are among the newly emerging environmental contaminants known to exhibit a lack of toxicological data, especially regarding the harmful effects and biomarkers of exposure and potential harm to the environment, which is a recent concern of the scientific community. The possible contamination of water sources for these compounds and the real possibility of shortages of fresh water in the near future, make it essential that the studies provide support for the preparation of legislation to adequately protect this natural resource. In Brazil, was recently published in Resolution 396 of the National Environment Advice (CONAMA), which tackles the groundwater reserves. Although this legislation is broad, does not include any of emerging contaminants, which can contaminate both surface water and underground reservoirs. The fact that the mitochondria be recognized as the main energy-producing cell organelles, as well as play a vital role in the maintenance of many cellular functions, makes it a great tool for the study of toxic activities of substances such as brominated flame retardants. Thus, this design is intended to provide data to the scientific community about the harmful effects of using PBDEs tests with isolated mitochondria in order to evaluate the toxicity of these compounds.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PAZIN, MURILO; PEREIRA, LILIAN CRISTINA; DORTA, DANIEL JUNQUEIRA. Toxicity of brominated flame retardants, BDE-47 and BDE-99 stems from impaired mitochondrial bioenergetics. TOXICOLOGY MECHANISMS AND METHODS, v. 25, n. 1, p. 34-41, . (09/06912-6, 12/04542-0)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SILVA, Murilo Pazin. Evaluation of the toxicity of BDE-47 and BDE-99 congeners of polybrominated biphenyl ether (PBDE) using mitochondrial assays. 2014. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (PCARP/BC) Ribeirão Preto.

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