The brominated flame retardants (highlighting polybrominated diphenyl ethers), are substances widely used in various consumer goods to increase their fire resistance and / or higher temperatures in case of fire, they reduce the spread of fire in interfering combustion of materials, thus increasing the chances of escape and reducing the severity of burns. The efficient control of the flame spread and low cost makes the polybrominated diphenyl ethers (PBDEs) the class is used for this purpose. These compounds are among the newly emerging environmental contaminants known to exhibit a lack of toxicological data, especially regarding the harmful effects and biomarkers of exposure and potential harm to the environment, which is a recent concern of the scientific community. The possible contamination of water sources for these compounds and the real possibility of shortages of fresh water in the near future, make it essential that the studies provide support for the preparation of legislation to adequately protect this natural resource. In Brazil, was recently published in Resolution 396 of the National Environment Advice (CONAMA), which tackles the groundwater reserves. Although this legislation is broad, does not include any of emerging contaminants, which can contaminate both surface water and underground reservoirs. The fact that the mitochondria be recognized as the main energy-producing cell organelles, as well as play a vital role in the maintenance of many cellular functions, makes it a great tool for the study of toxic activities of substances such as brominated flame retardants. Thus, this design is intended to provide data to the scientific community about the harmful effects of using PBDEs tests with isolated mitochondria in order to evaluate the toxicity of these compounds.
News published in Agência FAPESP Newsletter about the scholarship: