Interaction between photosensitizers derived of Protoporphyrin IX and mimetic membrane

• Grant number: 12/10049-4
• Support Opportunities: Scholarships in Brazil - Master
• Start date: August 01, 2012
• End date: October 31, 2013
• Field of knowledge: Physical Sciences and Mathematics - Chemistry
• Principal Investigator: Mauricio da Silva Baptista
• Grantee: Tayana Mazin Tsubone
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Photodynamic Therapy (PDT) is a treatment that use of the photosensitizer (PS) and light irradiation in the appropiate wavelength, inducing the photo-oxidation of biomolecules. Porphyrins photosensitizers has been widely used in PDT due appropriate characteristics to this treatment. It is know that addition the photochemical properties, the photo-activity of this compounds depends preferential association with biological membranes. The interaction between PS and model membrane, and consequently the photosensitizing efficiency is dependent on molecular structure. However, the molecular details relationship between the binding in membranes and generation of reactive species are unknown. Therefore, in this project we intend to correlate the efficiency of generation of singlet oxygen and the binding and localization in the membranes. For this, we will investigate the effect of positive charge in peripheral groups and chelation with zinc derivative of Pp IX in the efficiency and localization of binding to membranes. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

TSUBONE, TAYANA MAZIN; MARTINS, WALESKA KERLLEN; PAVANI, CHRISTIANE; JUNQUEIRA, HELENA COUTO; ITRI, ROSANGELA; BAPTISTA, MAURICIO S.. Enhanced efficiency of cell death by lysosome-specific photodamage. SCIENTIFIC REPORTS, v. 7, JUL 27 2017. (12/10049-4, 13/07937-8, 12/50680-5, 13/16532-1)