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Effect of ovulation induction therapy with hCG and deslorelin on folicular hemodynamics and endogenous profile of LH in cyclic mares

Grant number: 12/11117-3
Support type:Scholarships in Brazil - Master
Effective date (Start): August 01, 2012
Effective date (End): October 31, 2014
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Reproduction
Principal Investigator:Cezinande de Meira
Grantee:Yatta Linhares Boakari
Home Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
Associated scholarship(s):13/19772-3 - Effect of aromatase inhibition on follicular development, blood flow, ovulation and ovulation rate in the mare, BE.EP.MS


Use of ovulation inductors, such as hCG and deslorelin, is a common practice in equine reproduction. LH is a hormone responsible for maturation, ovulation and luteinizing of the dominant follicle and its plasmatic concentrations might be related with follicle's walls irrigation. The present study will have as main objective to evaluate the alterations in blood perfusion of dominant follicles due to the use of induction hormones and its temporal relationship with the plasmatic profile of LH. A total of 24 mares will be divided in three groups (n=8 mares/group) according with the ovulation induction treatment: a) Deslorelin Group (1,5mg of GnRH); b) hCG Group (2500 UI of hCG) and c) Control Group Saline (2mL of NaCl 0,9%). Treatments will be done when a dominant follicle with a diameter e 35mm associated with uterine edema are present. The moment immediately previous to the treatment will be considered as H0. Blood collection from the jugular vein and Doppler ultrasonography exam of the dominant follicle will be done to evaluate, respectively, the plasmatic concentration of LH and the follicular blood flow. The parameters will be evaluated every hour between intervals H0-H12 and H30-H48. Additionally, the same parameters will be collected every six hours from H12 to H30

Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
BOAKARI, Yatta Linhares. Efeito da hCG ou deslorelina sobre a hemodinâmica folicular e perfil endogeno de LH em éguas cíclicas. 2014. 27 f. Master's Dissertation - Universidade Estadual Paulista "Júlio de Mesquita Filho" Faculdade de Medicina Veterinária e Zootecnia..

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