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Sequential changes of autonomic cardiovascular control in young SHR submitted to aerobic training

Grant number: 12/10326-8
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): September 01, 2012
Effective date (End): March 31, 2016
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal Investigator:Lisete Compagno Michelini
Grantee:Adriana Ruggeri
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:11/51410-9 - Amelioration of the autonomic imbalances of old age with exercise: exploring the molecular and physiological mechanisms, AP.TEM


Previous studies in the chronic phase of hypertension (SHR ~ 3 months) have shown the effectiveness of aerobic training (T) to reverse / correct some of the functional deficits, showing in addition that these changes were related to plastic and functional adaptations of central autonomic pathways. Nothing is known about the potential benefits of exercise training started early, in the pre-hypertensive phase. In the present study we sought to analyze in the young SHR (~ 4 weeks old at the beginning of the protocols) and their normotensive controls the effects of aerobic training on the functional responses of the cardiovascular system (baseline blood pressure and heart rate, baroreflex sensitivity, sympathetic and parasympathetic tone to the periphery, variability of blood pressure and heart rate) and the associated changes on gene and protein expression in different autonomic areas integrating bulbar and suprabulbar cardiovascular control. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FERREIRA-JUNIOR, NILSON C.; RUGGERI, ADRIANA; SILVA JR, SEBASTIAO D.; ZAMPIERI, THAIS T.; CERONI, ALEXANDRE; MICHELINI, LISETE C. Exercise training increases GAD65 expression, restores the depressed GABA(A) receptor function within the PVN and reduces sympathetic modulation in hypertension. PHYSIOLOGICAL REPORTS, v. 7, n. 13 JUL 2019. Web of Science Citations: 0.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
RUGGERI, Adriana. Temporal evolution of autonomic control and cardiovascular responses associated in young SHR submitted of aerobic training.. 2016. Doctoral Thesis - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas São Paulo.

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