| Grant number: | 12/00635-3 |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| Start date: | October 01, 2012 |
| End date: | May 31, 2014 |
| Field of knowledge: | Health Sciences - Medicine - Medical Clinics |
| Principal Investigator: | Sergio Luiz Domingues Cravo |
| Grantee: | Aline Priscila Pansani |
| Host Institution: | Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil |
Abstract The obstructive sleep apnea (OSA) is the most common sleep disorder, and is related to arterial hypertension. Among the mechanisms proposed to explain this relationship is sympathetic overactivity. Our laboratory has developed a model of OSA in rats using an intratracheal balloon to cause upper airway occlusion. The objective of this study is to verify whether there is changes in blood pressure and autonomic modulation in the rat model of chronic OSA and which mechanisms are involved in these changes. We will use male Wistar rats submitted to the model of OSA. The rats will be separated into three groups: 1) SHAM (rats subjected to surgical procedures without apnea), 2) REM sleep apnea (obstruction only in REM sleep), 3) random apnea (Obstructions independent of sleep-wake cycle). The EEG recording will be made for a period of 24 hours for sleep staging.. To check the effect of chronic obstructive events, the apneas will be made for 30 days, followed by a recovery period of 30 days. The variables analyzed will be: blood pressure, heart rate variability, heart rate, oxygen saturation and ventricular function. Statistical analysis will be made according to the normality of the data. The significance will be 5%. | |
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