Association of Ancestry with Cardiovascular Disease Risk Factors in a Brazilian Population Sample: ELSA-Brasil

• Grant number: 12/11879-0
• Support Opportunities: Scholarships in Brazil - Master
• Start date: December 01, 2012
• End date: November 30, 2014
• Field of knowledge: Biological Sciences - Genetics - Human and Medical Genetics
• Principal Investigator: Alexandre da Costa Pereira
• Grantee: Hadassa Campos Santos
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

This research project's main objective is to associate genetic ancestry and ethnic self-reported in a Brazilian population of individuals with risk factors for cardiovascular disease. The study of a population with high genetic admixture, such as Brazil, provides ways of understanding the potential genetic influence in determining the phenotypes of complex diseases such as cardiovascular disease, in common ancestral roots. These studies are of major importance, since the results of such studies may be incorporated into the medical care, and can provide a direction closer to the diagnosis, treatment and quality of life of patients. For this study will use a sample of five thousand adults aged 35-74 years in São Paulo, linked to the Longitudinal Study of Adult Health (ELSA). The samples will be genotyped first and then subjected to statistical procedures to ensure the reliability of results. Following, will be conducted analyzes of association between genetic ancestry and ethnicity with aouto-reported cardiovascular risk factors such as high blood pressure, pulse wave velocity and obesity. It will be used for statistical models of association, as they have been successful in identifying the association of individual ancestry with characteristics of complex diseases. The development of the research project will be at the Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), Faculty of Medicine, University of Sao Paulo and is linked to the Longitudinal Study of Adult Health.

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

SANTOS, Hadassa Campos. Association of self-reported ethnicity and genetic ancestry with cardiovascular risk factors in a Brazilian population sample: ELSA - Brazil. 2015. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.