Effect of an alimentary supplement used in order to improve bone mineral density

• Grant number: 12/07319-0
• Support Opportunities: Scholarships abroad - Research
• Start date: February 10, 2013
• End date: February 09, 2014
• Field of knowledge: Health Sciences - Nutrition - Nutrition Biochemistry
• Principal Investigator: Antonio Herbert Lancha Junior
• Grantee: Antonio Herbert Lancha Junior
• Host Investigator: François Blachier
• Host Institution: Escola de Educação Física e Esporte (EEFE). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Institution abroad: Institut National de la Recherche Agronomique (INRA), France

Abstract

Among colonic metabolites, sulfide can be produced by the intestinal microbiota from alimentary and endogenous sulfur-containing compounds including amino acids. In excess, H2S is known to severely inhibit cytochrome oxidase, the terminal oxidase of the mitochondrial transport chain, and thus mitochondrial oxygen consumption. This can have deleterious effect on colonic function. For this purpose sulphide has been implicated in the aetiology of bowel disease. There are reasons to consider that environmental factors such as nutrition which is known to markedly modify the composition of the large intestine content, would play a key role in the etiology of inflammatory bowel disease. However the concept that sulfide is simply a metabolic troublemaker toward colonic epithelial cells has been challenged by the discovery that micromolar concentration of H2S is able to increase the cell respiration and to energize mitochondria allowing them to detoxify and to recover energy from. This study aimed to evaluate the impact of in vivo intraluminal injection of sulfide (0,5- 1,5mM) for 1 hour in the large intestine on oxidative metabolism and inflammatory parameter on isolated colonocytes. (AU)

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE CAMPOS-FERRAZ, PATRICIA LOPES; ANDRADE, ISABEL; DAS NEVES, WILLIAN; HANGAI, ISABELA; RODRIGUES ALVES, CHRISTIANO ROBLES; LANCHA, JR., ANTONIO HERBERT. An overview of amines as nutritional supplements to counteract cancer cachexia. JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE, v. 5, n. 2, p. 105-110, JUN 2014. (12/02682-9, 13/04744-4, 12/25240-1, 12/07319-0)

SOLIS, MARINA YAZIGI; ARTIOLI, GUILHERME GIANNINI; MONTAG, EDUARDO; PAINELLI, VITOR DE SALLES; SAITO, FABIO LOPES; LIMA, FERNANDA RODRIGUES; ROSCHEL, HAMILTON; GUALANO, BRUNO; LANCHA JUNIOR, ANTONIO HERBERT; BENATTI, FABIANA BRAGA. The Liposuction-Induced Effects on Adiponectin and Selected Cytokines Are Not Affected by Exercise Training in Women. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY, 2014. (11/08302-0, 12/07319-0, 13/04806-0)

CHAVES, DANIELA F. S.; CARVALHO, PAULO C.; LIMA, DIOGO B.; NICASTRO, HUMBERTO; LORENZETI, FABIO M.; SIQUEIRA-FILHO, MARIO; HIRABARA, SANDRO M.; ALVES, PAULO H. M.; MORESCO, JAMES J.; YATES, III, JOHN R.; et al. Comparative Proteomic Analysis of the Aging Soleus and Extensor Digitorum Longus Rat Muscles Using TMT Labeling and Mass Spectrometry. JOURNAL OF PROTEOME RESEARCH, v. 12, n. 10, p. 4532-4546, OCT 2013. (12/07319-0, 10/10852-6)

DE CAMPOS-FERRAZ, PATRICIA LOPES; ANDRADE, ISABEL; DAS NEVES, WILLIAN; HANGAI, ISABELA; RODRIGUES ALVES, CHRISTIANO ROBLES; LANCHA, ANTONIO HERBERT, JR.. An overview of amines as nutritional supplements to counteract cancer cachexia. JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE, v. 5, n. 2, p. 6-pg., 2014-06-01. (12/02682-9, 13/04744-4, 12/07319-0, 12/25240-1)

SOLIS, MARINA YAZIGI; ARTIOLI, GUILHERME GIANNINI; MONTAG, EDUARDO; PAINELLI, VITOR DE SALLES; SAITO, FABIO LOPES; LIMA, FERNANDA RODRIGUES; ROSCHEL, HAMILTON; GUALANO, BRUNO; LANCHA JUNIOR, ANTONIO HERBERT; BENATTI, FABIANA BRAGA. The Liposuction-Induced Effects on Adiponectin and Selected Cytokines Are Not Affected by Exercise Training in Women. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY, v. 2014, p. 6-pg., 2014-01-01. (13/04806-0, 12/07319-0, 11/08302-0)

PASQUA, LEONARDO A.; BUENO, SALOMAO; ARTIOLI, GUILHERME G.; LANCHA, ANTONIO H.; MATSUDA, MONIQUE; MARQUEZINI, MONICA V.; LIMA-SILVA, ADRIANO E.; SALDIVA, PAULO H. N.; BERTUZZI, ROMULO. Influence of ACTN3 R577X polymorphism on ventilatory thresholds related to endurance performance. JOURNAL OF SPORTS SCIENCES, v. 34, n. 2, p. 163-170, JAN 17 2016. (11/17059-2, 10/13913-6, 12/07319-0)