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Effect of an alimentary supplement used in order to improve bone mineral density

Grant number: 12/07319-0
Support type:Scholarships abroad - Research
Effective date (Start): February 10, 2013
Effective date (End): February 09, 2014
Field of knowledge:Health Sciences - Nutrition - Nutrition Biochemistry
Principal researcher:Antonio Herbert Lancha Junior
Grantee:Antonio Herbert Lancha Junior
Host: François Blachier
Home Institution: Escola de Educação Física e Esporte (EEFE). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Research place: Institut National de la Recherche Agronomique (INRA), France  

Abstract

Among colonic metabolites, sulfide can be produced by the intestinal microbiota from alimentary and endogenous sulfur-containing compounds including amino acids. In excess, H2S is known to severely inhibit cytochrome oxidase, the terminal oxidase of the mitochondrial transport chain, and thus mitochondrial oxygen consumption. This can have deleterious effect on colonic function. For this purpose sulphide has been implicated in the aetiology of bowel disease. There are reasons to consider that environmental factors such as nutrition which is known to markedly modify the composition of the large intestine content, would play a key role in the etiology of inflammatory bowel disease. However the concept that sulfide is simply a metabolic troublemaker toward colonic epithelial cells has been challenged by the discovery that micromolar concentration of H2S is able to increase the cell respiration and to energize mitochondria allowing them to detoxify and to recover energy from. This study aimed to evaluate the impact of in vivo intraluminal injection of sulfide (0,5- 1,5mM) for 1 hour in the large intestine on oxidative metabolism and inflammatory parameter on isolated colonocytes. (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PASQUA, LEONARDO A.; BUENO, SALOMAO; ARTIOLI, GUILHERME G.; LANCHA, ANTONIO H.; MATSUDA, MONIQUE; MARQUEZINI, MONICA V.; LIMA-SILVA, ADRIANO E.; SALDIVA, PAULO H. N.; BERTUZZI, ROMULO. Influence of ACTN3 R577X polymorphism on ventilatory thresholds related to endurance performance. JOURNAL OF SPORTS SCIENCES, v. 34, n. 2, p. 163-170, JAN 17 2016. Web of Science Citations: 6.
DE CAMPOS-FERRAZ, PATRICIA LOPES; ANDRADE, ISABEL; DAS NEVES, WILLIAN; HANGAI, ISABELA; RODRIGUES ALVES, CHRISTIANO ROBLES; LANCHA, JR., ANTONIO HERBERT. An overview of amines as nutritional supplements to counteract cancer cachexia. JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE, v. 5, n. 2, p. 105-110, JUN 2014. Web of Science Citations: 16.
SOLIS, MARINA YAZIGI; ARTIOLI, GUILHERME GIANNINI; MONTAG, EDUARDO; PAINELLI, VITOR DE SALLES; SAITO, FABIO LOPES; LIMA, FERNANDA RODRIGUES; ROSCHEL, HAMILTON; GUALANO, BRUNO; LANCHA JUNIOR, ANTONIO HERBERT; BENATTI, FABIANA BRAGA. The Liposuction-Induced Effects on Adiponectin and Selected Cytokines Are Not Affected by Exercise Training in Women. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY, 2014. Web of Science Citations: 6.
CHAVES, DANIELA F. S.; CARVALHO, PAULO C.; LIMA, DIOGO B.; NICASTRO, HUMBERTO; LORENZETI, FABIO M.; SIQUEIRA-FILHO, MARIO; HIRABARA, SANDRO M.; ALVES, PAULO H. M.; MORESCO, JAMES J.; YATES, III, JOHN R.; LANCHA, JR., ANTONIO H. Comparative Proteomic Analysis of the Aging Soleus and Extensor Digitorum Longus Rat Muscles Using TMT Labeling and Mass Spectrometry. JOURNAL OF PROTEOME RESEARCH, v. 12, n. 10, p. 4532-4546, OCT 2013. Web of Science Citations: 18.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.