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Evaluating the use of pantoprazole and preconditioning for renal protection in rats subjected to ischemia / reperfusion under inhalation anesthesia with isoflurane

Grant number: 12/16457-7
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): November 01, 2012
Effective date (End): December 31, 2014
Field of knowledge:Health Sciences - Medicine - Surgery
Principal Investigator:Norma Sueli Pinheiro Módolo
Grantee:Ana Carolina Brito Pavan
Home Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

INTRODUCTION - The phenomenon of ischemia and reperfusion (I / R) is present so often during some surgical procedures such as coronary angioplasty, organ transplantation, surgical procedures involving the clamping of vessels and myocardial revascularization. This is the situation where an organ or tissue is exposed to an ischemic event which determines an end result with varying degree of impact varying from one cell dysfunction necrosis, and after some time reestablishes the flow. Once blood flow is restored (reperfusion) of the affected area, a new injury can be established, leading to damage phones1.OBJECTIVE - The objective of this study is to analyze the use of pantoprazole in protecting kidneys subjected to preconditioning in rats under general anesthesia with isoflurane.MATERIAL AND METHODS - The animals are anesthetized with isoflurane inhalation in inspired concentration of 3% to 4%, maintaining, and included randomized into four study groups Group C: inhalation anesthesiaGroup IR: inhalation anesthesia + renal ischemiaGroup P: inhalation anesthesia + pantoprazolePIR Group: inhalation anesthesia + + pantoprazole renal ischemiaAll groups will undergo laparotomy and right nephrectomy for the purpose of establishing the right kidney as control of the left kidney after ischemia.