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EVALUATION OF DEEP VENOUS THROMBOSIS BY STASIS MODEL IN INSULINE RESISTENCE AND OBESE ANIMALS

Grant number: 12/12396-3
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): November 01, 2012
Effective date (End): February 29, 2016
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal researcher:Joyce Maria Annichino-Bizzacchi
Grantee:Fernanda Dutra Santiago Bassora
Home Institution: Centro de Hematologia e Hemoterapia (HEMOCENTRO). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Deep venous thrombosis (DVT) is defined as the occlusion of a vessel of the venous system. The physiopathology of DVT is based in alteration of vascular wall and / or blood elements. The investigation of other risk factors involved in DVT is of great importance, since some studies suggest a correlation between venous thromboembolism (VTE) with risk factors for coronary artery disease (obesity, diabetes and hypertension). The use of animal models for the study of venous thrombosis can enable analysis of parameters that can not be investigated in humans, such as the evaluation of the components present in venous thrombosis after arterial occlusion.In this study will be used swiss mice, which will be submitted to a high fat diet to obtain the risk factors for coronary artery and after 8 weeks of diet-induced DVT is in stenosis. This study aims to induce DVT in obese animals and / or insulin resistant in order to assess the size and formation of thrombus formed.This study will be conducted in four stages, the first step to assess clinical signs artery disease such as body weight, and fasting glucose, cholesterol and triglycerides. In the second step to analyze thrombus formation using the intravital microscopy. In the third stage, will be assessed the weight and size of the thrombus formed in groups and in the last step will be carried out immunohistochemical analysis of thrombus formed.

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