Influence of hypoinsulinemic-hyperglycemic condition on the expression of toll-like receptors 2 and 4 in subpopulations of peripheral monocytes for murine dermatophytic infection

• Grant number: 12/20031-5
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: December 01, 2012
• End date: November 30, 2014
• Field of knowledge: Biological Sciences - Immunology - Applied Immunology
• Principal Investigator: James Venturini
• Grantee: Débora de Fátima Almeida
• Host Institution: Faculdade de Ciências (FC). Universidade Estadual Paulista (UNESP). Campus de Bauru. Bauru , SP, Brazil

Abstract

In recent years, several researchers have emphasized the role of TLRs in different pathologies. In Diabetes Mellitus patients were observed an increased expression of 2 and 4 TRLs. However, the mechanisms and consequences of these changes are not elucidated. Regarding the dermatophyte infection, we did not found studies involving these receptors. In other fungal infections, such as paracoccidioidomycosis, it has been suggested that despite the TLR-2 activation facilitates the fungal infection by to inhibit the triggering of Th17 inflammatory cells, there is a beneficial effect to the host. On the other hand, TLR-4 activation leads to a severe infection associated with an enhanced inflammatory activity and an impaired T regulatory response. Considering the paucity of data and the relevance of this subject, our aim is evaluate the expression of TRL-2 and TRL-4 on peripheral blood monocytes subsets during the HH condition, the dermatophyte infection and in both situation. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ALMEIDA, DEBORA DE FATIMA; DE CAMPOS FRAGA-SILVA, THAIS F.; SANTOS, AMANDA R.; FINATO, ANGELA C.; MARCHETTI, CAMILA M.; GOLIM, MARJORIE DE ASSIS; LARA, VANESSA S.; ARRUDA, MARIA S. P.; VENTURINI, JAMES. TLR2(-/-) Mice Display Increased Clearance of Dermatophyte Trichophyton mentagrophytes in the Setting of Hyperglycemia. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, v. 7, JAN 20 2017. (10/16917-2, 12/20031-5)