Implication of the prenatal exposition to the drug market as crack cocaine in the physical and reproductive development of the offspring of rats

• Grant number: 12/10245-8
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: March 01, 2013
• End date: September 30, 2013
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Pathology
• Principal Investigator: Helenice de Souza Spinosa
• Grantee: Virgínia Martins Carvalho
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The crack cocaine use has become popular in recent years. Smoking cocaine base also causes an intense craving, has a high addictive potential, and is associated with human marginalization. The use for young women represents an important risk for the public health. In case of a pregnant the drug crosses the placental barrier and causes effects on the offspring. Considering there are rare studies about crack cocaine reproductive effects and the drug is involved with high pregnant rates and use for all gestational period, the investigation about the perinatal exposition is useful for the evaluation of the effects on neurobehavioral and health of children. The objective of this project is the characterization of maternal reproductive effects and neurobehavioral offspring effects from the prenatal crack cocaine exposition. (AU)