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Changes in melatonin, leptin and corticosterone production in rats subjected to day restricted feeding during pregnancy and lactation

Grant number: 12/20320-7
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): January 01, 2013
Effective date (End): December 31, 2013
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal Investigator:Gabriel Forato Anhê
Grantee:Jessica Meulman
Home Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


Circadian variations in food intake are inwardly synchronized with metabolic rhythms and endocrine oscillations. Medical findings demonstrate that patients that eat up to 50% of their daily caloric needs during the night are predisposed to obesity. In addition, these patients high morning levels of cortisol, morning anoerexia and reduced nocturnal levels of melatonin and leptin. Similarly to humans, rodents that are forced to eat during the light phase of the light dark cycle gain more weight, become obese and secrete less melatonin during the night when compared to their ad libitum counterparts. Besides these circadian variations, endocrine secretions are subjected to fine tuning during temporal limited conditions such as pregnancy. During gestation, rats display transitory insulin resistance and increased leptin, melatonin and corticosterone levels. Some of these adaptations are resumed to non-pregnant state during lactation. So far, it is not known IF changes in the feeding Schedule are able to modulate the endocrine adaptation of pregnancy and lactation. Thus, the aims of the present study is to evaluate if day restricted feeding during pregnancy and lactation are able to interfere in the changes of melatonin, leptin, insulin and corticosterone levels often detected during these periods.