UPPER AIRWAY COLLAPSIBILITY TRHOUGH THE CRITICAL CLOSING PRESSURE TECHNIQUE DURING SLEEP AND THE NEGATIVE EXPIRATORY PRESSURE TEST DURING WAKEFULNESS AND SLEEP IN OBSTRUCTIVE SLEEP APNEA AND NORMAL SUBJECTS.

• Grant number: 12/20743-5
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: February 01, 2013
• End date: March 31, 2016
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Geraldo Lorenzi Filho
• Grantee: Raquel Pastréllo Hirata
• Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

Obstructive sleep apnea (OSA) is a breathing disorder characterized by collapse of the upper airway during sleep. Oropharyngeal muscle exercises during wakefulness may improve the severity of OSA. However, the relationship between the collapsibility of the upper airway during wakefulness and sleep is poorly understood. We have recently validated the pharyngeal critical closing pressure technique by applying a variable pressure in a nasal mask during induced sleep using midazolam. The negative expiratory pressure test evaluates the collapsibility of the upper airway during wakefulness, being modified and validated by the group of Professor Insalaco for the study of OSA. The central hypothesis of this study is that there is a correlation between the collapsibility of the upper airway during wakefulness and sleep. The primary objective of this study is therefore to compare and correlate the collapsibility of the upper airway determined using the pharyngeal critical closing pressure technique during sleep and negative expiratory pressure test during wakefulness and sleep in patients with OSA and healthy individuals. Forty-five subjects of both sexes and aged between 18 and 65 will participate in this study, who will be divided into groups (n = 15) of normal, mild OSA and moderate-to-severe OSA. Volunteers will perform pulmonary function testing, full overnight polysomnography, assessment of critical closing pressure of the pharynx during sleep and negative expiratory pressure test during wakefulness and sleep. We hope to contribute to a better understanding of the pathophysiology of OSA by assessing the behavior of the upper airway during wakefulness and sleep.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

HIRATA, RAQUEL P.; SCHORR, FABIOLA; KAYAMORI, FABIANE; MORIYA, HENRIQUE TAKACHI; ROMANO, SALVATORE; INSALACO, GIUSEPPE; GEBRIM, ELOISA M.; FRANCO DE OLIVEIRA, LUIS VICENTE; GENTA, PEDRO R.; LORENZI-FILHO, GERALDO. Upper Airway Collapsibility Assessed by Negative Expiratory Pressure while Awake is Associated with Upper Airway Anatomy. JOURNAL OF CLINICAL SLEEP MEDICINE, v. 12, n. 10, p. 1339-1346, 2016. (11/12120-5, 12/20743-5)

HIRATA, RAQUEL PASTRELLO; KAYAMORI, FABIANE; SCHORR, FABIOLA; MORIYA, HENRIQUE TAKACHI; ROMANO, SALVATORE; INSALACO, GIUSEPPE; GEBRIM, ELOISA; FRANCO DE OLIVEIRA, LUIS VICENTE; GENTA, PEDRO RODRIGUES; LORENZI-FILHO, GERALDO. Influence of interface and position on upper airway collapsibility assessed by negative expiratory pressure. Sleep and Breathing, v. 21, n. 3, p. 631-638, SEP 2017. (12/20743-5, 11/12120-5)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

HIRATA, Raquel Pastréllo. Upper airway collapsibility evaluation during wakefulness using negative expiratory pressure and during sleep using pharyngeal critical closing pressure in obstructive sleep apnea and normal subjects. 2016. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.